Results 81 to 90 of about 30,965,369 (298)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Penerapan TAM dengan Penambahan Variabel Trust dan Risk untuk Mengukur Penerimaan Aplikasi OnlinePajak

open access: yesJurnal Masyarakat Informatika, 2020
OnlinePajak adalah sebuah aplikasi e-filing yang digunakan untuk menghitung nominal pajak, melakukan pembayaran pajak, dan melaporkan pembayaran pajak. Pengguna aplikasi OnlinePajak belum terlalu banyak. Penelitian ini dilakukan untuk mengukur penerimaan
Wulan Tri Lestari, Edy Suharto
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Perceptions of electronic filing (e-filing) among tax agents in northern region of Malaysia [PDF]

open access: yes, 2005
Electronic filing is one of electronic services provided by Inland Revenue Board (IRB) in order to assist tax agents in submitting the tax return electronically and as its initiative towards Electronic Government. It is a process of submitting tax return
Abd. Khalid, Ahmad Zamil   +2 more
core   +1 more source

PENGARUH PERSEPSI KEGUNAAN DAN PERSEPSI KEMUDAHAN PENGGUNAAN TERHADAP HUBUNGAN ANTARA PERSEPSI PENERAPAN SISTEM E-FILING DENGAN TINGKAT KEPATUHAN WAJIB PAJAK BADAN YANG DIMEDIASI OLEH PERILAKU WAJIB PAJAK (Studi Kasus Pada Kantor Pelayanan Pajak Pratama Jakarta Pulo Gadung)

open access: yesProfita, 2017
The purpose of this study is to find empirical evidence on: 1) The effect of perception of the application of e-filing system to taxpayer compliance; 2) Effect of perception of e-filing system implementation on Taxpayer's behavior; 3) The influence of ...
Veronica Nensi Panca Herina
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

PENGARUH PENERAPAN E-REGISTRATION, E-FILING, E-BILLING DAN E-SPT TERHADAP KEPATUHAN WAJIB PAJAK UMKM PADA KPP PRATAMA SURAKARTA [PDF]

open access: yes, 2021
Tujuan dari penelitian ini adalah untuk menguji kembali dan membuktikan kembali penelitian terdahulu yang dilakukan oleh Ersania dan Merkusiwati (2018) pada subjek penelitian yang berbeda yaitu Wajib Pajak UMKM yang terdaftar pada KPP Pratama ...
Santiastri, Dea Gracia
core  

The Effect of Volume of Transaction On The Intention Towards Tax E-filing

open access: yesSHS Web of Conferences, 2017
Volume of transaction is specifically referring to number of clients or return forms dealing by tax agents/preparers. This variable does play role even though there is less empirical evidence on this matter.
Aziz Saliza Abdul, Idris Kamil Md
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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