Results 141 to 150 of about 30,846,279 (306)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Pengujian Performa Mesin E-FILL Dalam Proses Pengisian Air Pada Botol

Journal of Computer, Electronic, and Telecommunication
Dalam sebuah industri skala kecil maupun dalam skala besar, otomatisasi sangat berpengaruh dalam jalannya kinerja dan pengoptimalan sistem. Seperti merancang atau mengembangkan sebuah mesin filling cairan otomatis. Selain itu dengan adanya sistem otomatis dapat meringankan tenaga kerja dalam hal ini adalah operator mesin.
Muhammad Dzi Washfil Hasin, Dwi Rizky Anto, Muhammad Dhifa Alfitra, Deni Almunawar, Mohammad Abu Jami’in Abu Jami’in, Ryan Yudha Adhitya, Ii’ Munadhif, Anggara Trsina Nugraha, Dimas Pristovani Riananda, Zindhu Maulana Ahmad Putra, Mohammad Fajar Adiatmoko   +10 more
openaire   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

E-FILLING, PEMAHAMAN PERPAJAKAN, DAN SOSIALISASI: KUNCI MENINGKATKAN KEPATUHAN WAJIB PAJAK

Jurnal Akuntansi, Keuangan, Perpajakan dan Tata Kelola Perusahaan
Penelitian ini bertujuan untuk menguji dan menganalisis : (1) Pengaruh Penerapan E-Filling terhadap Kepatuhan Wajib Pajak Orang Pribadi, (2) Pengaruh Pemahaman Perpajakan terhadap Kepatuhan Wajib Pajak Orang Pribadi, (3) Pengaruh Sosialisasi Perpajakan terhadap Kepatuhan Wajib Pajak Orang Pribadi,.
Auliya Nida’Us Sholihah, Nera Marinda Machdar   +1 more
openaire   +1 more source

Easy Money Back Option using Simple Internet Based E-Filling Form

International Journal of Innovative Technology and Exploring Engineering, 2019
It is a taking an interest non-connected arrangement which offers an alluring blend of security against death all through the term of the arrangement alongside the occasional installment on endurance at determined spans during the term. This one of a kind mix gives money related help to the group of the perished policyholder whenever before development
openaire   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

CardiacModelling/space-filling-designs: Version 1.1

<p>Code associated with the paper "Optimal experimental designs for characterising ion channel gating by filling the phase-voltage space of model dynamics" by Mirams et al.
Gary Mirams
core   +1 more source

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition with widely varying global prevalence estimates. The frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the United States or United Kingdom, at 19 to 39 per 100,000 as opposed ...
Lucinda Roper, Rachel Black, Joanna Tieu, Winnie Chen, Matthew Parker, Catherine Hill, Natasha Nassar, Mandana Nikpour   +7 more
wiley   +1 more source