Results 161 to 170 of about 2,336,778 (334)

Adaptação cultural e validação do "attentional function index" para a cultura brasileira

, 2007
Carla Klava dos Reis
openalex   +1 more source

Tu1268 REFLUX CONDITIONS-INDUCED E-CADHERIN CLEAVAGE AND EPITHELIAL-TO-MESENCHYMAL TRANSITION IS MEDIATED BY APE1 REDOX FUNCTION IN ESOPHAGEAL ADENOCARCINOMA [PDF]

, 2023
Heng Lu, Long‐Long Cao, Farah Ballout, Abbes Belkhiri, Dunfa Peng, Lei Chen, Zheng Chen, Mohammed Soutto, Timothy C. Wang, Jianwen Que, Oliver G. McDonald, Alexander Zaika, Wael El‐Rifai   +12 more
openalex   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Transcendence of values of logarithms of $E$-functions

Let $f$ be an $E$-function (in Siegel's sense) not of the form $e^{βz}$, $β\in \overline{\mathbb{Q}}$, and let $\log$ denote any fixed determination of the complex logarithm. We first prove that there exists a finite set $S(f)$ such that for all $ξ\in \overline{\mathbb{Q}}\setminus S(f)$, $\log(f(ξ))$ is a transcendental number.
Fischler, Stéphane, Rivoal, Tanguy
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Integrals of products of E-functions

Mathematische Annalen, 1959
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source