Results 41 to 50 of about 32,759,036 (278)

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Riappare un “déjà vu” nella giurisprudenza: la responsabilità oggettiva del vescovo per gli atti illeciti dei suoi sacerdoti

Stato, Chiese e Pluralismo Confessionale, 2013
Contributo sottoposto a valutazione SOMMARIO: 1. La “novità” dell’ordinanza del Tribunale di Lecce 8 ottobre 2012 – 2. Il precedente belga – 3. Uno sguardo sulla dottrina civilistica del respondeat superior nell’esperienza americana – 4.
Angelo Licastro
doaj   +1 more source

Polymer‐Grafted Cu(II) Metal–Organic Polyhedra as Scalable, Melt‐Processable Porous Materials

Advanced Science, EarlyView.
The use of a direct synthetic route to obtain polymer‐grafted Cu(II)‐based metal–organic polyhedra gives rise to a low‐cost and scalable cage. This material combines low‐temperature melting, achieving phase changes while preserving cage integrity, and high CO2 uptake exceeding 0.6 mmol g−1.
Alba Cortés‐Martínez, Francisco Sánchez‐Férez, José A. Suárez del Pino, Sergio Royuela, Félix Zamora, Daniel Maspoch, Arnau Carné‐Sánchez   +6 more
wiley   +1 more source

A TRADIÇÃO EUROPEIA EM SOCIEDADE UNIPESSOAL: COMPARAÇÃO COM O BRASIL - DOI: 10.12818/P.0304-2340.2013v63p491

Revista da Faculdade de Direito da Universidade Federal de Minas Gerais, 2014
O presente trabalho apresenta a tradição europeia na adoção da sociedade unipessoal de responsabilidade limitada, além de outras figuras que visam à limitação da responsabilidade do empresário individual, de modo a contrapor com a realidade brasileira ...
Maíra Leitoguinhos de Lima Abreu
doaj   +4 more sources

Multi‐Scale Bionic Structure Constructs Biomass Flame‐Retardant Thermal Insulation Foam Material

Advanced Science, EarlyView.
Inspired by mussel adhesion and hierarchical brick‐and‐mortar architectures, a cellulose‐based biomimetic foam is constructed by anchoring bentonite nanosheets onto a polydopamine‐decorated cellulose nanofiber network. The resulting foam combines low thermal conductivity with intrinsic flame retardancy and full biodegradability, presenting a ...
Jianming Liao, Lijun Fan, Yunyuan Dong, Xuyu Bao, Xiaobin Chen, Qifu Zheng, Guanqing Zhang, Shen Wang, Wei Chen, Min Zhang, Shuaiming He   +10 more
wiley   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

Advanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

A responsabilidade civil ambiental decorrente da obsolescência programada/Environmental civil liability arising from planned obsolescense

Revista Brasileira de Direito, 2015
Este artigo pretende demonstrar, através de uma pesquisa bibliográfica, jurisprudencial e documental, que a obsolescência programada é uma estratégia empresarial a estimular o consumismo desenfreado.
Gabriella Castro Vieira, Elcio Nacur Rezende   +1 more
doaj   +1 more source

GUARANTEEING THE ACCES OF THIRD PARTIES TO THE NETWORK INDUSTRIES SPECIFIC INFRASTRUCTURES – A VITAL COMPONENT OF EU'S POLICY IN THE FIELD OF COMPETITION ON THE ENERGY MARKET, IN THE CONTEXT OF THE NEED TO INSURE ENERGY INDEPENDENCE WHILE MANTAINING AFFORDABLE PRICES [PDF]

Challenges of the Knowledge Society, 2023
As both the practical experience and the theoretical constructions of successive generations of practitioners and researchers of the phenomenon of the economy and the legal norms associated with its proper functioning have proven, the most important ...
Iulian BĂICULESCU, Dragoș-Adrian BANTAȘ   +1 more
doaj  

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

As funções preventivas e precaucionais da responsabilidade civil por danos ambientais

Sequência: Estudos Juridicos e Politicos, 2007
O objetivo deste artigo é examinar a responsabilidadecivil ambiental, no âmbito da jurisdiçãobrasileira, e as transformações sofridas por esteinstituto na tentativa de adequar-se às necessidadesde prevenção e precaução dos riscos ambientais.Primeiramente,
Melissa Ely Melo, José Rubens Morato Leite   +1 more
doaj