Results 171 to 180 of about 23,402,107 (303)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TECHNOLOGY ADOPTION, CAPITAL MAINTENANCE AND THE TECHNOLOGICAL GAP [PDF]

We study optimal growth models à la Nelson and Phelps (1966) where labor resources can be allocated either to production, technology adoption or capital maintenance. We first characterize the balanced growth paths of a benchmark model without maintenance.
Raouf Boucekkine, Blanca Martínez, CARGI SAGLAM   +2 more
core  

Stakeholder priorities for sustaining operations and maintenance of school sanitation facilities in Kampala City, Uganda. [PDF]

Discov Public Health
Byansi JZ, Semiyaga S, Katukiza AY, Bateganya NL, Nakaye AM, Kansiime F, Kulabako RN.   +6 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Anti-EGFR-based maintenance versus stop and go in patients with left-sided, non-MSI-H, RAS/BRAF-wt metastatic colorectal cancer: individual patient data pooled analysis. [PDF]

ESMO Open
Raimondi A, Tinè G, Boige V, De Stefano A, Ballhausen A, Gourgou S, Giuliani F, Stahler A, Randon G, Prisciandaro M, Manca P, Ambrosini M, Fazio R, Mohamed S, Gronchi G, Santabarbara G, Brument E, Alig AHS, Miceli R, Bouche O, Modest DP, Avallone A, Pietrantonio F.   +22 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Treatment evolution and survival impact of consolidation therapies in mantle cell lymphoma: insights from an Asia-Pacific real-world registry. [PDF]

Blood Cancer J
Cho H, Kato K, Chan JY, Dajung K, Huang H, Cai Q, Lin T, Bunworasate U, Tan SM, Kang KW, Kwak JY, Chen TY, Lee JO, Jeong SH, Do YR, Chan E, Kang HJ, Eom HS, Oh SY, Koh Y, Kim HJ, Kim SH, Won JH, Park YH, Yang DH, Ng SC, Jo JC, Tadjoedin H, Lubis AM, Sutandyo N, Muta T, Takase K, Yoon DH, Kim WS.   +33 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Software Product Support and Maintenance Outsourcing Prepared By EXECUTIVE SUMMARY

, 2008
4 72%: percentage of software product companies who will release a new product each year 4 9 months: s/w product life cycle 4 < 10%: success rate of new products 4 60%: average percentage of maintenance costs to the total cost in the product life ...
Goldstone Technologies, Maintenance Outsourcing   +1 more
core  

Quizartinib for patients with newly diagnosed FLT3-ITD-positive AML who received maintenance therapy in QuANTUM-First. [PDF]

Blood Adv
Levis MJ, Erba HP, Montesinos P, Patkowska E, Cortes J, Perl AE, Dombret H, Amadori S, Wang J, Schlenk RF, Liu L, Mostafa Kamel Y, Imadalou K, Laadem A, Burns K, Sekeres MA.   +15 more
europepmc   +1 more source