Results 231 to 240 of about 1,182,951 (299)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Peanut oral immunotherapy at a single academic medical center using a volume-based approach with store-purchased peanut products. [PDF]

J Allergy Clin Immunol Glob
Devonshire AL, Magier AZ, Wilson BE, Rosenberg C, Winslow A, Risma KA, Abonia JP, Sherenian MG, Assa'ad AH, Andorf S, Schwartz JT.   +10 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Durable progression-free survival with first-line sintilimab plus chemotherapy followed by sintilimab maintenance in PD-L1-high recurrent cervical cancer: a case report. [PDF]

Front Oncol
Liu J, Ren WJ.
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Case Report: Two cases of primary malignant melanoma of the female genital tract and literature review. [PDF]

Front Immunol
Li Q, Zeng J, Li X, Huang M, Wu Y, Wang J, Chen H.   +6 more
europepmc   +1 more source

Urban road surface crack detection based on U-net and ResNeXt network. [PDF]

PLoS One
Qiao J, Wang H, Zhou Z, Meng Y, Gong M.
europepmc   +1 more source

Superoxide dismutases maintain niche homeostasis in stem cell populations. [PDF]

Elife
Majhi O, Chhatre A, Chaudhary T, Sinha D.   +3 more
europepmc   +1 more source

The STRENGTH Study: A cluster randomised controlled trial of the effect of a behaviour change intervention added to cardiac rehabilitation on physical activity adherence. [PDF]

PLoS One
Doherty CTM, Tully MA, Wilson JJ, Heron L, McAneney H, Irving V, Spratt L, O'Reilly R, Kensitt K, Blackburn NE.   +9 more
europepmc   +1 more source