Results 201 to 210 of about 19,981,156 (315)

Neuroblastoma Angiogenesis Is Inhibited with a Folded Synthetic Molecule Corresponding to the Epidermal Growth Factor-Like Module of the Follistatin Domain of SPARC

Cancer Research, 2004
A. Chlenski, Shuqing Liu, L. Baker, Qiwei Yang, Yufeng Tian, H. Salwen, S. Cohn   +6 more
semanticscholar   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Development and Pilot Evaluation of an e-Learning Module for Autologous Fat Transfer (AFT) in Total Breast Reconstruction in the Dutch Healthcare System: Insights From 9 Plastic Surgeons. [PDF]

Adv Med Educ Pract
Van der Venne WBW, Van Laar S, Joosten-Ten Brinke D, Piatkowski A, Heuts EM, Renden PG.   +5 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity. [PDF]

Commun Med (Lond)
Rider A, Grantham HJ, Smith GR, Watson DS, Casement J, Cockell SJ, Gisby J, Foulkes AC, Henkin R, Iqbal WA, Ewen T, Amarnath S, Ng S, Zuliani P, Dand N, Stocken D, Traini C, Thomas E, Kalyana-Sundaram S, Rajpal DK, Smith KM, Barker JN, Griffiths CEM, Di Meglio P, Smith CH, Warren RB, Barnes MR, Reynolds NJ, PSORT consortium.   +28 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Correction: DeltaBreed: A BrAPI-centric breeding data information system. [PDF]

PLoS One
Yarnes SC, Palladino N, Meidlinger DJ, Philips DR, Sweeney HM, Mustafa SA, Mandych ML, Bouabane S, Parsons TE, Slonecki TJ, Zhao D, Rife TW, Ellerbrock BJ, Courtney C, Selby P, Mueller LA, Flores-Gonzalez M, Aparicio JS, Al-Sham'aa K, Raubach S, Jannink JL, Buckler ES, Beil CT, Sheehan MJ.   +23 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

From isolation to insights: mitochondrial complex I in the diatom Phaeodactylum tricornutum. [PDF]

Plant J
Berdun F, Senkler J, Senkler M, Ditz N, Plönnigs E, Reinard T, Zabaleta E, Braun HP.   +7 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source