Results 191 to 200 of about 1,983,299 (303)

Electronic Participation: 10th IFIP WG 8.5 International Conference, ePart 2018, Krems, Austria, September 3-5, 2018, Proceedings

Electronic Participation, 2018
Noella Edelmann, P. Parycek, G. Misuraca, P. Panagiotopoulos, Y. Charalabidis, Shefali Virkar   +5 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rehabilitation outcomes of older persons within the context of the International Classification of Functioning, Disability and Health (ICF): a systematic review. [PDF]

Eur Geriatr Med
Brouwer VHEW, Schuijt HJ, Visser-Meily JMA, Achterberg WP, van Dam van Isselt EF.   +4 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Bamboo worm collection activity and the changes in rural livelihoods in Yunnan Province, China. [PDF]

J Ethnobiol Ethnomed
Li Y, Hirota I.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic Cascade Screening for Familial Hypercholesterolemia: A Randomized Clinical Trial.

JAMA Netw Open
Nanchen D, Chaouch A, Scuderi R, Faivre V, von Känel T, Ehret G, Brun N, Sudano I, Rickli H, Girod G, Dettwiler AB, Krasieva K, Podmore C, Rodondi N, Moutzouri E, Ballhausen D, Del Giorno R, von Eckardstein A, Beer JH, Gallino A.   +19 more
europepmc   +1 more source

Development and Psychometric Evaluation of the Functional Vision Scale for Adults. [PDF]

Healthcare (Basel)
Temuçin K, Akı E.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Feasibility of an incentivised exercise program to improve the health of physically inactive Australian hospital employees - the Fitbites pilot study. [PDF]

Prev Med Rep
Madronio CM, Tyler A, Stanbury L, Low GKK, Nirthanakumaran DR, Stamatakis E, Negishi K, Pathan F.   +7 more
europepmc   +1 more source