Results 221 to 230 of about 882,596 (264)

Independence in activities of daily living for home-based geriatric rehabilitation after shortened inpatient rehabilitation: The “Better@Home” multicentre prospective cohort study with a matched historical control group.

Gamble C, Vaz M, de Waal M, Groen W, Pol M, Isselt EvDv, Innocenti F, Zwakhalen S, Haastregt Jv.   +8 more
europepmc   +1 more source

Enjoyment as a motivational driver of sport continuation: a moderated mediation model of engagement and social support. [PDF]

Front Psychol
Kaçay Z, Seçer E, Yıldız NO, Esentürk OK, Talaghir LG, Bentea CC, Ivan P, Cristea F.   +7 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Feasibility of an App-Based Worksite Health Promotion Program to Improve Mental Well-Being and Work-Related Vitality in University Hospital Workers: Process and Preliminary Effect Evaluation Study. [PDF]

JMIR Form Res
Kremers SHM, Beulens JWJ, Middel CNH, Elders PJM, van der Beek AJ, Rutters F.   +5 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The brain network underlying social participation: a multimodal, data-driven investigation. [PDF]

Brain Imaging Behav
Casburn MG, Laighneach A, Doherty E, Quilligan F, Fernandes A, Corley E, Donohoe G, Broin PÓ, Morris DW, Cannon DM.   +9 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Children's Health-Related Quality of Life After Brachial Plexus Birth Injury.

JAMA Netw Open
Bauer AS, Manske MC, Dorich JM, Miller PE, Aguiar R, Al-Muhtaseb T, Allgier A, Miller M, Davidge KM, Cornwall R.   +9 more
europepmc   +1 more source

Encouraging Adults at Risk for Type 2 Diabetes to Enroll in Diabetes Prevention Programs Through a Media Campaign in Hawai'i: Cross-Sectional Study. [PDF]

JMIR Public Health Surveill
Saiki K, Lim E, Nett B, Ogawa G, Ching LK, Kawasaki RM, Barreto NA, Inoue K, Irvin LH, Kaupiko KR, Keliikoa LB, McGurk MD.   +11 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source