Results 31 to 40 of about 52,325 (236)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Public procurement system as an effective tool e-government to combat corruption in Ukraine in the context of e-democracy

Aspekti Publìčnogo Upravlìnnâ, 2020
The paper presents the results of a study on the implementation of the public procurement system as an effective tool of e-government aimed at preventing corruption offenses.
Lesia Rozhak
doaj   +1 more source

Blockchain, Enterprise Resource Planning (ERP) and Accounting Information Systems (AIS): Research on e-Procurement and System Integration

Applied Sciences, 2021
Accounting information systems (AISs), the core module of any enterprise resource planning (ERP) system, are usually designed as centralised systems. Nowadays, the continuous development and applications of blockchain, or more broadly—distributed ledger ...
Alessio Faccia, Pythagoras Petratos
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

A Concept of a Digital and Traceable Manufacturing Documentation Based on Formalized Process Description Applied on Composite Aircraft Moveable

Advanced Engineering Materials, EarlyView.
The documentation of component manufacture has become an essential part of today's production processes, especially for the analysis and optimization of production or component design with regard to structural performance, economic efficiency, and sustainability.
Björn Denker, Dominik Delisle, Christian Krombholz, Martin Rädel, Frank Dressel   +4 more
wiley   +1 more source

Compressible Flow Exfoliation of Two‐Dimensional Nanomaterials: Insights Into Layer Separation Informed by Gas Dynamics

Advanced Engineering Materials, EarlyView.
This study elucidates the mechanism of compressible flow exfoliation for producing 2D hexagonal boron nitride (h‐BN). Fluid dynamics analysis reveals that acceleration‐driven aerodynamic shear forces, rather than shock waves alone, drive effective layer separation.
Md Farhadul Islam, Saeed Arabha, Ray Hixon, Reza Rizvi   +3 more
wiley   +1 more source

Transfer of Energy and Momentum Between Magnetoactive Surface Microstructure and a Solid Object

Advanced Engineering Materials, EarlyView.
We demonstrate that magnetoactive multilamellar arrays subjected to a rotating magnetic field can function as platforms for controlled transport of physical objects. Through systematic experimental investigation, we elucidate the underlying physical mechanisms determining the upper limit of the achievable transportation speed in such magnetic “conveyor‐
Arne Geldof, Jan Kopačin, Izidor Straus, Raphael Kriegl, Gaia Kravanja, Luka Hribar, Matija Jezeršek, Mikhail Shamonin, Gašper Kokot, Irena Drevenšek‐Olenik   +9 more
wiley   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

THE USE OF PROCUREMENT MARKETPLACES BY THE INSTUTUTIONS OF PUBLIC SECTOR – POTENCIAL BENEFIT ANALYSIS

Nowoczesne Systemy Zarządzania, 2016
The purpose of this article is to present the possibilities of using internet purchasing platforms by public sector institutions and the resulting benefits.
Agnieszka ŚCISŁO
doaj   +1 more source