Results 111 to 120 of about 1,076,927 (287)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
On the model of hybrid electronic publishing
Библиосфера, 2013 The model of a hybrid publishing, developed and approved on the basis of the Bulgarian publishing house «e-Book» is presented. The functional characteristics of the model and the tasks of marketing communications for hybrid electronic publishing-house ...
E. .. Pavlovskja, M. .. Milanova
doaj
GDL: a model infrastructure for a regional digital library [PDF]
, 2002 This brief article describes the early days of the Glasgow Digital Library (GDL), when it was a cross-sectoral and city-wide collaborative initiative involving Strathclyde, Glasgow and Caledonian Universities, as well as Glasgow City Libraries and ...
Dawson, A., Macgregor, G., Nicholson, D.
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Global & Regional Health Technology Assessment, 2019 In the randomized, active-controlled, multicenter Phase III open-label ALEX trial, alectinib showed superior efficacy and lower toxicity compared with crizotinib in the primary treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer ...
Ravasio R +5 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Exploiting information needs and bibliographics for polyrepresentative document clustering [PDF]
, 2014 In this paper we explore the potential of combining the principle of polyrepresentation with document clustering. Our idea is discussed and evaluated for polyrepresentation of information needs as wells as for document-based polyrepresentation where ...
Abbasi, Muhammad Kamran, Frommholz, Ingo
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
0032 | Beyond Neutrosophic Graphs (E-Publisher)
, 2022 Henry Garrett, (2022). Beyond Neutrosophic Graphs , Ohio: E-publishing: 873 Educational Publisher 1091 West 1st Ave Grandview Heights, Ohio 43212 874 United States. ISBN: 978-1-59973-725-6 875 (http://fs.unm.edu/BeyondNeutrosophicGraphs.pdf). In this outlet, a journey amid three models are designed. Graphs, fuzzy graphs and neutrosophic graphs are
openaire +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source