Results 41 to 50 of about 22,509,631 (312)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

E-book – śmierć książki czy jej nowe życie? Historia, technologia, poezja, rynek

open access: yesAnnales Universitatis Paedagogicae Cracoviensis. Studia de Cultura, 2016
The purpose of the article is to present the subject of electronic literature’s place in modern world, specifics of this form of publishing and opportunities it carries. The history of e-books formation from 1971 to present day is outlined – changes that
Mateusz Nizianty, Anna Piechota
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A leitura, a produção de sentidos e o processo inferencial Reading, sense production and the inferential process

open access: yesPsicologia em Estudo, 2004
Na produção de sentidos de textos, o leitor desempenha papel ativo, sendo as inferências um relevante processo cognitivo nesta atividade. Este artigo defende o argumento de que a compreensão da leitura não é orientada apenas pelas marcas gráficas do ...
Sandra Patrícia Ataíde Ferreira   +1 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Comprensión de textos expositivos académicos en e-book Reader y en papel: influencia del conocimiento previo de dominio y la aptitud verbal

open access: yesCiencias Psicológicas, 2018
En un estudio del que participaron 102 estudiantes universitarios, se comparó la comprensión en la lectura de textos expositivos académicos impresos versus en formato de e-book Reader. Se examinaron los efectos del soporte, del conocimiento específico de
Silvia Piovano   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Leitor e leituras: considerações sobre gêneros textuais e construção de sentidos Reader and reading: considerations about text types and meaning construction

open access: yesPsicologia: Reflexão e Crítica, 2005
O presente artigo aborda a leitura como uma atividade de construção de sentidos que implica a relação dinâmica entre leitor e texto. Primeiramente, apresenta-se a idéia de que a leitura varia de acordo com o leitor e seus objetivos, concebendo-a como uma
Sandra Patrícia Ataíde Ferreira   +1 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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