Results 111 to 120 of about 714,481 (251)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Multiple Case Study Investigation of E-Reader Devices in Academia

open access: yes, 2012
E-texts are seen as the imminent direction for education publishers. There are many e-reader devices currently available, leading to a variety of device characteristics that might affect use of the device, and more importantly, impact behaviors that can ...
Scharff, Lauren
core  

Reader Arquitecture Characterization for Chipless Wireless Sensors Applications. [PDF]

open access: yes, 2017
The main goal of this project is to design, implement and characterize a portable chipless reader for resonator chipless tags by comparing it with a non-portable chipless reader.
Villa-González, F. (Fátima)   +1 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Design and Implementation of a Compact and Long Range Monostatic UHF RFID Reader with Read Point Extension [PDF]

open access: yes, 2014
22nd IEEE Signal Processing and Communications Applications Conference (SIU) -- APR 23-25, 2014 -- Karadeniz Teknik Univ, Trabzon, TURKEYIn this paper, a compact and long range monostatic UHF (Ultra High Frequency) RFID (Radio Frequency Identification ...
Topaloglu, Serkan   +3 more
core  

The Evolution of Metadata from Standards to Semantics in E-Learning Applications

open access: yes, 2006
Metadata attempts to describe the content, format, purpose and structure of data. Over the past few years, the IEEE-LOM standard has dominated the metadata world in e-learning applications.
Davis, Hugh C.   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

CARD READER

open access: yes, 2010
The rapid development of electronic world-sized chips are currently produced many havebeen implemented in a card-card technology that will replace the previously used magneticdata.
RISTYAWATI RISTYAWATI RISTYAWATI; dosen
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

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