GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors
FEBS Open Bio, EarlyView.GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.To mimic the LH action in the ovary, granulosa‐cell and mouse models were stimulated by hCG, which changed RNA profiles within extracellular vesicles (EVs), and potentially hCG‐responsive EV RNAs increased the number of recipient ovarian cells. EV‐associated RNAs are potential intermediaries of hCG signaling.
Natchanok Puangjit +6 more
wiley +1 more source
Artificial Intelligence in Pancreatic Cancer: From Predictive Performance to Clinical Translation. [PDF]
Cancers (Basel)Khan I +7 more
europepmc +1 more source
Ethical Foreground and Background in Adult Educator Work
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley +1 more source
Programmable Genome Sensing with Visual, Fluorescence, and Glucometer Readings: Cell-Free In Vitro Translation Approach Using RNA Switch-CRISPR. [PDF]
BiochemistryLashkari M +5 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller +14 more
wiley +1 more source
Near-Field Communication-Enabled Wearable Chemical Sensors for Bioanalytical Monitoring. [PDF]
Chem Asian JChe H +6 more
europepmc +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
Development of shelf-stable reagents and assay kits for bioluminescence applications using the capillary-assisted vitrification platform stabilization technology. [PDF]
PLoS OneRadford S +14 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay +13 more
wiley +1 more source