Results 151 to 160 of about 22,054,732 (308)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Freedom Readers The African American Reception of Dante Alighieri and the Divine Comedy

Freedom Readers: The African American Reception of Dante Alighieri and the Divine Comedy is a literary-historical study of the many surprising ways in which Dante Alighieri and the Divine Comedy have assumed a position of importance in African American ...
Looney, Dennis.
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Chapter 3: E-Readers Now, E-Readers Forever!

, 2012
While a tablet is a sort of “magic window” that becomes whatever you want via apps, the e-reader is a device almost entirely dedicated to a single function, that of reading long-form text.
Griffey, Jason
core  

Editorial Expression of Concern: Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation. [PDF]

Respir Res
Mazzon E, Cuzzocrea S.
europepmc   +1 more source

Consensus-Level and Cluster-Adjusted Evaluation of a Large Language Model for Diagnostic Extraction from Musculoskeletal Radiology Reports. [PDF]

Diagnostics (Basel)
Bosbach WA, Montazeri E, Senge JF, Beisbart C, Mitrakovic M, Anderson SE, Divjak E, Ivanac G, Grieser T, Weber MA, Sanal HT, Daneshvar K.   +11 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Open-Source Artificial Intelligence in Small-Bowel Capsule Endoscopy-Visual Assistance is Promising, But Not Yet a Standard of Care. [PDF]

DEN Open
Toth E, Koulaouzidis A.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

"Cities of Readers" at IMC Leeds 2017

, 2017
This year two members of "Cities of Readers" presented papers at the International Medieval Congress 2017 in Leeds: Sabrina Corbellini presented a paper entitled Spiritual Landscapes in Late Medieval Florence: Letters and Networks in the session ...
Margriet Hoogvliet
core