Results 251 to 260 of about 63,809,003 (360)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Annotated checklist of the amphibians and reptiles of Zacatecas, Mexico. [PDF]

Zookeys
Sigala-Rodríguez JJ, Carbajal-Márquez RA, Encarnación-Luévano A, Lara-Galván JL, Bañuelos-Alamillo JA, Centenero-Alcalá E, Ahumada-Carrillo IT, Carmona-Torres FH.   +7 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Synchronous Rotation Dynamics in a Molecular Motor. [PDF]

J Am Chem Soc
Kluifhooft R, Wilhelmsen J, Kapitzke M, Rückert AK, Kovalenko SA, Ioffe IN, Stähler J, Kathan M, Palato S.   +8 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Low-emissivity materials for building applications: A state-of-the-art review and future research perspectives

, 2015
B. P. Jelle, S. E. Kalnæs, T. Gao
semanticscholar   +1 more source

Architecting three-dimensional reconfigurable matter from pop-up kirigami with programmable multistability. [PDF]

Sci Adv
Zhou T, Huang C, Zhao H, Liu J, Liu K, Chen D, Li Y.   +6 more
europepmc   +1 more source

Shylock's Nationalism : The Ideas of Nation and (E) state in The Merchant of Venice

Shylock's Nationalism : The Ideas of Nation and (E) state in The Merchant of Venice
Article Archaeology of Intellectual Aspects of European Culture, P.77 ...
openaire  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Correction: Working to Increase Stability through Exercise (WISE): screening, recruitment, and baseline characteristics. [PDF]

Trials
Sciamanna CN, Ballentine NH, Bopp M, Chinchilli VM, Ciccolo JT, Delauter G, Fisher A, Fox EJ, De Beur SMJ, Kearcher K, Kraschnewski JL, Lehman E, McTigue KM, McAuley E, Paranjape A, Rodriguez-Colon S, Rovniak LS, Rutt K, Smyth JM, Stewart KJ, Stuckey HL, Tsay A.   +21 more
europepmc   +1 more source