Results 81 to 90 of about 63,809,003 (360)

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

open access: yesPLoS ONE, 2015
Breast cancer stem cells (CSCs) are thought to drive recurrence and metastasis. Their identity has been linked to the epithelial to mesenchymal transition (EMT) but remains highly controversial since—depending on the cell-line studied—either epithelial ...
A. Grosse‐Wilde   +8 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Bronchopulmonary Pathology Prevalence Among Premature infants and Estimation of Prophylactic Efficacy and Reactogenicity of 13-Valent Pneumococcal Conjugate Vaccine in Premature infants with Bronchopulmonary Dysplasia

open access: yesПедиатрическая фармакология, 2020
Background. The most frequent chronic lung pathology among infants and especially in premature children with extremely low and very low body weight is bronchopulmonary dysplasia (BPD).
Vladislav V. Semerikov   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Report on audit of financial statements South Carolina State Accident Fund as of and for the year ended June 30, 2023

open access: yes, 2023
The Office of the State Auditor annually publishes a report on financial statements of the South Carolina State Accident Fund. This audit is a statement of net assets of the agency and the related statements of revenues, expenses, and changes in net ...
South Carolina State Auditor   +1 more
core  

Privacy Preservation in e-Healthcare Environments: State of the Art and Future Directions

open access: yesIEEE Access, 2018
e-Healthcare promises to be the next big wave in healthcare. It offers all the advantages and benefits imaginable by both the patient and the user. However, current e-Healthcare systems are not yet fully developed and mature, and thus lack the degree of ...
Muneeb Ahmed Sahi   +8 more
semanticscholar   +1 more source

REGULARITIES OF FORMATION OF FLOW OF COOLANT BEHIND THE TVS-KVADRAT MIXING SPACING GRID OF THE PWR-TYPE REACTOR

open access: yesИзвестия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2018
Tgratinghis paper presents the results of experimental investigations of the influence of mixing spacer gratings with different types of deflectors on the coolant flow in the TVSKvadrat fuel assembly of the PWR-type reactor. Experimental model of the TVS-
S. M. Dmitriev   +4 more
doaj   +1 more source

IMPROVING THE EFFICIENCY OF URBAN TRANSPORT INFRASTRUCTURE BASED ON DIGITAL TECHNOLOGIES

open access: yesВестник университета, 2020
The need to improve the efficiency of transport infrastructure, which is an important subsystem of urban services as a determinant of the quality of life of the city’s population, has been substantiated.
S. N. Gagarina   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Experimental Study of Coherent Collaborative Processing Method in Distributed Automotive Radar

open access: yesИзвестия высших учебных заведений России: Радиоэлектроника
Introduction. Intelligent driver assistance systems are increasingly employing radar systems to detect, resolve, and track various classes of targets. The use of MIMO-based distributed systems allow the characteristics of object resolution by angle to be
A. A. Kuzin   +4 more
doaj   +1 more source

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