Results 241 to 250 of about 9,853,288 (268)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

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Pnicogen, halogen and hydrogen bonds in (E)-1-(2,2-dichloro-1-(2-nitrophenyl)vinyl)-2-(para-substituted phenyl)-diazenes

Dyes and pigments, 2018
Schiff base condensation of 2-nitrobenzaldehyde with (para-substituted phenyl)hydrazine in the presence of CH3COONa in EtOH at 80 °C produces (E)-1-(para-substituted phenyl)-2-(2-nitrobenzylidene)hydrazines [−OCH3 (1), −CH3 (2), −H (3), −Br (4), −Cl (5),
A. Maharramov, N. Shikhaliyev, G. T. Suleymanova, A. Gurbanov, G. Babayeva, G. Mammadova, F. Zubkov, V. Nenajdenko, K. Mahmudov, A. Pombeiro   +9 more
semanticscholar   +1 more source

Lax formalism for q-Painleve equations with affine Weyl group symmetry of type E^{(1)}_n

, 2010
An explicit form of the Lax pair for the q-difference Painleve equation with affine Weyl group symmetry of type E^{(1)}_8 is obtained. Its degeneration to E^{(1)}_7, E^{(1)}_6 and D^{(1)}_5 cases are also given.
Y. Yamada
semanticscholar   +1 more source

Synthesis, spectroscopic (FT-IR, FT-Raman, NMR, UV–Visible), NLO, NBO, HOMO-LUMO, Fukui function and molecular docking study of (E)-1-(5-bromo-2-hydroxybenzylidene)semicarbazide

, 2017
M. Raja, R. Muhamed, S. Muthu, M. Suresh
semanticscholar   +1 more source

High-Efficiency Class- $\mbox{E}^{-1}$ and Class-F/E Power Amplifiers at Any Duty Ratio

IEEE transactions on industrial electronics (1982. Print), 2016
A. Sheikhi, Mohsen Hayati, A. Grebennikov   +2 more
semanticscholar   +1 more source

Structural, third-order optical nonlinearities and figures of merit of ( E )-1-(3-substituted phenyl)-3-(4-fluorophenyl) prop-2-en-1-one under CW regime: New chalcone derivatives for optical limiting applications

, 2017
Anusha N. Ekbote, P. S. Patil, S. Maidur, Tze Shyang Chia, C. Quah   +4 more
semanticscholar   +1 more source

E 1. Zeit

Althochdeutsche Grammatik I, 2018

semanticscholar   +1 more source

Tutor-e 1

, 2019
Jesús López Belmonte, Santiago Pozo Sánchez, Gema Belmonte León, Arturo Fuentes Cabrera   +3 more
semanticscholar   +1 more source