Results 101 to 110 of about 14,129 (290)

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier   +3 more
wiley   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera   +6 more
wiley   +1 more source

CASA DE VEGETAÇÃO E TIPOS DE SUBSTRATOS NO DESENVOLVIMENTO INICIAL DE Tectona grandis (L.f.)

open access: diamond, 2020
AMANDA CAROLINE DO AMARAL   +3 more
openalex   +1 more source

DENSITOMETRIA DE RAIOS X NA MADEIRA E CARVÃO DE CLONE DEEucalyptus grandis W. Hill ex Maiden X Eucalyptus urophylla S. T. Blake1 [PDF]

open access: gold, 2016
Marina Donária Chaves Arantes   +4 more
openalex   +1 more source

Cellular mechanisms of radiation‐induced myocyte dysfunction: effects on calcium handling, ion channel regulation and mitochondrial energetics

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley   +1 more source

Multiscale mechanistic modelling of heterogeneity in cardiac sub‐cellular calcium handling accounting for variable t‐system density

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman   +2 more
wiley   +1 more source

Biologia comparada e consumo foliar de Anisodes sp. (Lepidoptera: Geometridae) em folhas novas e velhas de Eucalyptus grandis W. Hill ex maid (Myrtaceae) e Psidium guajava l. (Myrtaceae)

open access: yesBioscience Journal, 2006
Anisodes sp. (Lepidoptera: Geometridae) foi encontrada causando danos em mudas de Psidium guajava L. (Myrtaceae) e Eucalyptus grandis W. Hill ex Maid (Myrtaceae) em Viçosa, Minas Gerais e teve sua biologia estudada em laboratório a 25±2ºC, umidade ...
Germi Porto Santos   +4 more
doaj  

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato   +3 more
wiley   +1 more source

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