Results 111 to 120 of about 34,733 (247)
IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente +17 more
wiley +1 more source
ABSTRACT Background The NEED (Needs Examination, Evaluation and Dissemination) framework provides a structured, multidimensional approach to assess unmet health‐related needs at both patient and societal levels, using predefined criteria, indicators and standardised data collection tools (e.g., questionnaire and interview guide).
Zilke Claessens +15 more
wiley +1 more source
Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia +6 more
wiley +1 more source
Abstract Intracontinental deformation records how early Eocene India–Asia collisional stress propagated into continental interiors. How rapidly compression reached the far field, and whether coeval Paleo‐Pacific slab dynamics contributed, remain debated. The Longzhong Basin, ∼1,900 km north of the collisional zone, provides a key test.
Zhantao Feng +8 more
wiley +1 more source
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
A Jellium‐guided strategy enables the unprecedented stabilization of ligand‐free Group 13 all‐metal clusters into ionic superlattices, overturning the Zintl paradigm and defining a new class of bandgap‐tunable, facile exfoliation quantum materials. ABSTRACT While considerable progress has been made in synthesizing ligand‐free all‐metal clusters (LFAMCs)
Jun Li +7 more
wiley +1 more source
Transformations in embryonic motility in chick: kinematic correlates of type I and II motility at E9 and E12. Soon after hatching, chicks exhibit an array of adaptive, coordinated behaviors.
Nina S. Bradley
core +1 more source
Phenolic Glycosides From Ficus erecta and Their Anti‐Inflammatory and Neuroprotective Activities
Five new phenolic glycosides, ficuserectosides A‐E (1–5), along with three known congeners (6–8) were isolated and identified from Ficus erecta. Compounds 5 and 8 protect PC12 cells from oxidative damage by decreasing reactive oxygen species (ROS) and increasing glutathione (GSH), highlighting their potential as neuroprotective leads.
Wenming Wu +4 more
wiley +1 more source

