Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells [PDF]
IL-22, a signature cytokine for type 3 lymphoid cells, including T helper 17/22 (Th17/22) and type 3 innate lymphoid cells (ILC3), mediates epithelial homeostasis and protective pathogen responses in barrier tissues.
Ankita Saini +11 more
doaj +2 more sources
Upregulation of a CFTR mRNA isoform has therapeutic potential for the treatment of 3′ CFTR PTC variants [PDF]
Nonsense or premature termination codon (PTC) variants of the CFTR gene are pathogenic and found in ∼10% of North American people with cystic fibrosis.
Normand E. Allaire +15 more
doaj +2 more sources
The Mechanism of Bladder Injury in Fetal Rats With Myelomeningocele
BackgroundBladder dysfunction has been implicated as a major cause of progressive renal failure in children with neurogenic bladder. However, its pathogenesis remains unclear.
Ying Liu +5 more
doaj +1 more source
Slow Transition Path Times Reveal a Complex Folding Barrier in a Designed Protein
De-novo designed proteins have received wide interest as potential platforms for nano-engineering and biomedicine. While much work is being done in the design of thermodynamically stable proteins, the folding process of artificially designed proteins is ...
Alexander Mehlich +4 more
doaj +1 more source
Domestic capital vs. foreign capital new enterprise creation: the case of FDI in India
The attempt of this paper is to find an empirical relationship between Foreign Direct Investment and New Firms (Paid up Capital) and Gross Capital Formation (proxy for business growth) and Credit to Commercial Sector and Gross Capital Formation using the
Sajikumar Tulasidharan +1 more
doaj +1 more source
The Impact of the Inflow of Foreign Direct Investments on the Economic Development of Serbia
Foreign direct investments present one of the very important products of globalization, by establishing a new economic concept of free international movement of capital, people, goods and services.
Kovačević Slaviša +2 more
doaj +1 more source
This study uses experiments and surveys from 146 participants who participated in equity trading to explore the predictive power of the Big-five personality traits, social behaviours, along with self-attribution and demographic characteristics on trading
Huan Huu Nguyen +3 more
doaj +1 more source
Intangible Assets, Goodwill and Earnings Management: Evidence from France and the Uk
Research background: The literature has argued that accounting for intangible assets and goodwill provides a wide range for managers to manipulate earnings.
Kimouche Bilal
doaj +1 more source
Resolving kinesin stepping: one head at a time
This study shows for the first time a qualitative difference in the stepping of a heterodimeric motor and the asymmetric influence of autoinhibition on the stepping of one of the heads.
Willi L Stepp, Zeynep Ökten
doaj +1 more source
Subnanometre enzyme mechanics probed by single-molecule force spectroscopy
Adenylate kinase catalyses the interconversion of adenosine phosphates, and plays a crucial role in maintaining cellular energy homeostasis. Here, the authors use single molecule optical tweezers to understand how the enzyme’s conformation dynamics ...
Benjamin Pelz +4 more
doaj +1 more source

