Results 121 to 130 of about 223,299 (305)

A Tobacco Homolog of DCN1 is Involved in Cellular Reprogramming and in Developmental Transitions [PDF]

, 2011
Plant proteomes show remarkable plasticity in reaction to environmental challenges and during developmental transitions. Some of this adaptability comes from ubiquitin-mediated protein destruction regulated by cullin-RING E3 ubiquitin ligases (CRLs ...
Alexandra Ribarits, Klaus Palme, Marina Baumann, Elisabeth Ankele, Katarzyna Szaszka, Viktor Voronin, Christina Friedmann, Julia Hosp, Alisher Touraev, Yongfeng Jin, Alisher Tashpulatov, Erwin Heberle-Bors, Tatiana Resch   +12 more
core  

Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]

, 2000
This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia, Lane, David P., T. Hay, Ronald, Hay, Ronald Thomas, Rodriguez, Manuel S, Desterro, Joana M P   +6 more
core   +1 more source

The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F

mSphere, 2016
The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny.
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette   +5 more
doaj   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Ubiquitin E3 ligase MARCH10 targets influenza hemagglutinin for ubiquitination

Cellular Signalling
Influenza virus infection damages the airways and can cause acute lung injury. Influenza virus infection remains difficult to combat since treatment is limited to supportive care or antiviral drugs to prevent influenza early in the condition. Influenza hemagglutinin (HA) is the surface glycoprotein that facilitates viral entry by binding to sialic acid-
Tsai, MuChun, Koch, Dan, Forchione, Anna, Farkas, Laszlo, El-Mergawy, Rabab, Londino, James D., Mallampalli, Rama K.   +6 more
openaire   +2 more sources

Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2010 Patani.Background: Ubiquitin modification of proteins influences cellular processes relevant to carcinogenesis.
Jiang, W, Newbold, R, Kefah Mokbel, Patani, Neill, Neill Patani, Mokbel, K, Robert Newbold, Jiang, Wen Guo, Newbold, Robert, Patani, N, Wen Jiang, Mokbel, Kefah   +11 more
core   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Optineurin negatively regulates the induction of IFNβ in response to RNA virus infection [PDF]

, 2010
The innate immune response provides a critical defense against microbial infections, including viruses. These are recognised by pattern recognition receptors including Toll-like receptors (TLRs) and RIG-I like helicases (RLHs).
Harris, M., Macdonald, A., Kohl, A., Richards, KH, Wetherill, L, Kohl, Alain, MacDonald, A, Mankouri, Jamel, Kohl, A, Elliott, Richard M., Elliott, RM, Alain Kohl, Wetherill, L.F., Rennos Fragkoudis, Harris Mark, Andrew Macdonald, Richards Kathryn H., Richards, K.H., Richards, K, Laura F Wetherill, Mankouri, J., Richards, Kathryn H., Mankouri, J, Jamel Mankouri, Elliott, R.M., Wetherill Laura F., Fragkoudis, R., Richard M Elliott, Macdonald, Andrew, Harris, M, Wetherill, Laura F., Kohl Alain, Elliott Richard M., Macdonald Andrew, Wetherill, LF, Elliott, Richard Michael, Mark Harris, Harris, Mark, Fragkoudis, R, Kathryn H Richards, Fragkoudis, Rennos, Mankouri Jamel, Fragkoudis Rennos   +42 more
core   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source