Dual effects of mefenamic acid on the IKs molecular complex
Abstract Background and Purpose Mutations in both KCNQ1 and KCNE1, which together form the cardiac IKs current, are associated with inherited conditions such as long and short QT syndromes. Mefenamic acid, a non‐steroidal anti‐inflammatory drug, is an IKs potentiator and may be utilised as an archetype to design therapeutically useful IKs agonists ...
Magnus Chan+5 more
wiley +1 more source
BackgroundInterventions using mobile health (mHealth) apps have been effective in promoting healthy lifestyle behavior change and hold promise in improving health outcomes to thereby reduce health disparities among diverse racial/ethnic populations ...
Bender, Melinda S+5 more
doaj +1 more source
Correction to ‘Patients with sickle cell disease who develop end‐stage kidney disease continue to experience poor survival – a 19‐year United States renal data system study’WinerJC, YeeME, AtagaKI, LebensburgerJD, ZahrRS. Patients with sickle cell disease who develop end‐stage kidney disease continue to experience poor survival – a 19‐year United States renal data system study. Br J Haematol2022; 199(5):e43‐e47. doi: https://doi.org/10.1111/bjh.18494 [PDF]
openalex +1 more source
Rates of multi-partite entanglement transformations and applications in quantum networks
The theory of the asymptotic manipulation of pure bipartite quantum systems can be considered completely understood: The rates at which bipartite entangled states can be asymptotically transformed into each other are fully determined by a single number ...
Eisert, J., Meignant, C., Streltsov, A.
core +2 more sources
Directed evolution of cytochrome P450BM3 to utilize a bacterial communication molecule, C10‐HSL, as an effective decoy molecule has been carried out. The evolved P450BM3 mutant shows high activity toward both in vitro and in vivo hydroxylation of benzene with C10‐HSL. Moreover, benzene hydroxylation without synthesis and addition of decoy molecules was
Yuya Yokoyama+6 more
wiley +1 more source
BackgroundSmartphones and other mobile devices are having and will continue to have an impact on health care delivery in acute settings in Australia and overseas.
Farrell, Maureen
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A monthly monetary model with banking intermediation for the euro area [PDF]
JEL Classification: C32, E41, E43, E50, G21Banking intermediation, cointegration, Loan demand, Money demand, Structural ...
Bruggeman, Annick, Donnay, Marie
core
Quantizing Mishchenko-Fomenko subalgebras for centralizers via affine W-algebras
We use affine W-algebras to quantize Mishchenko-Fomenko subalgebras for centralizers of nilpotent elements in simple Lie algebras under certain assumptions that are satisfied for all cases in type A and all minimal nilpotent cases outside type $E_8 ...
Arakawa, Tomoyuki, Premet, Alexander
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This paper presents an optimisation method for an inserted‐shunt integrated planar transformer based on 3D simulation in Ansys Maxwell. The optimisation objective is enhanced efficiency and power density for the transformer. The study shows that the optimisation enhances the efficiency and power density of the inserted‐shunt integrated planar ...
Sajad A. Ansari+2 more
wiley +1 more source
BackgroundAdequate self-management is the cornerstone of preventing type 1 diabetes mellitus (T1DM) complications. However, T1DM self-management is challenging for young people, who often struggle during the transition from childhood to adulthood.
Husted, Gitte Reventlov+3 more
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