Results 41 to 50 of about 4,491 (218)

The R.O.A.D. to precision medicine

npj Digital Medicine
We propose a novel framework that addresses the deficiencies of Randomized clinical trial data subgroup analysis while it transforms ObservAtional Data to be used as if they were randomized, thus paving the road for precision medicine.
Dimitris Bertsimas, Angelos Georgios Koulouras, Georgios Antonios Margonis   +2 more
doaj   +1 more source

Fragment‐Based Screening of Heterocyclic Electrophiles Identified Acrylamide Bioisoteres for Covalent KRasG12C Inhibitors

Archiv der Pharmazie, Volume 359, Issue 9, September 2026.
We screened acrylamide bioisosteres against KRasG12C and prioritized primary hits by their GSH reactivity, labeling efficiency and specificity. The most promising fragment was combined with a KRas‐binding scaffold. Covalent binding, inhibitory activity and selectivity were confirmed via MS, NMR, biochemical and cell viability assays.
Nikolett Péczka, Aaron Keeley, Péter Ábrányi‐Balogh, Zoltán Orgován, László Petri, Emma K. Grant, Chad Quinn, Soma Csanády, Ivan Randelovic, József Tóvári, Jacob Bush, György M. Keserű   +11 more
wiley   +1 more source

The Political Philosophy of Postgrowth and Degrowth

Philosophy Compass, Volume 21, Issue 5, September/October 2026.
ABSTRACT This article discusses the emerging field of the political philosophy of degrowth and postgrowth. ‘Postgrowth’ and ‘degrowth’ are visions of socio‐economic systems that do not focus on GDP and economic growth, but rather on sustainable prosperity, that is, wellbeing within planetary boundaries.
Catarina Neves, Ingrid Robeyns
wiley   +1 more source

Fiscal policy responsiveness, persistence, and discretion

, 2010
Fiscal policy, Fiscal volatility, E62, H50,
António Afonso, Afonso, A, Afonso, António, Davide Furceri, Luca Agnello, AGNELLO, Luca, FURCERI, Davide   +6 more
core   +1 more source

The Scandinavian model—prospects and challenges [PDF]

, 2007
Fiscal sustainability, Welfare state, Demographics, Globalisation, H1, E62, F22, P1,
Torben M. Andersen, Torben Andersen, Andersen, Torben M.   +2 more
core   +1 more source

Fiscal Federalism, Tax Independence and Social Enhancement

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2022
The tax autonomy of Nigeria’s three tiers of government is examined in this study to estimate the value of revenue fiscal decentralization in increasing citizens’ social welfare.
Omodero Cordelia Onyinyechi
doaj   +1 more source

Monetary-fiscal policies interactions and optimal rules in Egypt [PDF]

Review of Economics and Political Science, 2020
Purpose – This paper aims to estimate a New Keynesian small open economy dynamic stochastic general equilibrium (DSGE) model for Egypt using Bayesian techniques and data for the period FY2004/2005:Q1-FY2015/2016:Q4 to assess monetary and fiscal policy ...
Sherine Al-shawarby, Mai El Mossallamy
doaj   +1 more source

The public economics of self control

, 2008
Self-control, Merit Want, E62–H1,
Sang Bae, Attiat Ott, Bae, Sang Hoo, Ott, Attiat F.   +3 more
core   +1 more source

S3‐Leitlinie Diagnostik und Therapie der Alopecia areata – Teil 2: Therapie, psychosoziale und kosmetische Unterstützung

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page 1155-1179, August 2026.
Zusammenfassung In diesem zweiten Teil der S3‐Leitlinie zur Diagnostik und Therapie der Alopecia areata (AA) stellen wir die zentralen Inhalte und Empfehlungen zur topischen und systemischen Therapie, zur Lebensqualität und zu Unterstützungsangeboten vor.
Ulrike Blume‐Peytavi, Andria Constantinou, Tsenka Tomova‐Simitchieva, Adrian Tanew, Michael Sticherling, Hermann Girschick, Annika Vogt, Uwe Schwichtenberg, Uwe Gieler, André Märtens, Kerstin Zienert, Claudia Stenders, Ricardo Niklas Werner, Doris Wilborn   +13 more
wiley   +1 more source

S3 guideline diagnostics and therapy in alopecia areata – Part 2: Therapy, psychosocial and cosmetic support

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page e1155-e1177, August 2026.
Summary This second part of the S3 guideline on the diagnosis and treatment of alopecia areata (AA), presents key recommendations on topical and systemic therapy, quality of life and support services. The first part of the guideline, published separately, covers the definition and content of epidemiology and diagnosis as well as comorbidities, risk and
Ulrike Blume‐Peytavi, Andria Constantinou, Tsenka Tomova‐Simitchieva, Adrian Tanew, Michael Sticherling, Hermann Girschick, Annika Vogt, Uwe Schwichtenberg, Uwe Gieler, André Märtens, Kerstin Zienert, Claudia Stenders, Ricardo Niklas Werner, Doris Wilborn   +13 more
wiley   +1 more source