Results 11 to 20 of about 942 (186)

A Novel Technology Platform for Extracellular Vesicle-Targeted Expression of Drug-Metabolizing Enzymes: Driving CYP3A4 Expression and Secretion via the EABR Motif [PDF]

Biomedicines
Background: Cytochrome P450 3A4 (CYP3A4) is a key membrane-anchored drug-metabolizing enzyme. Its expression and purification in heterologous systems are severely hindered by low yield and detergent-induced structural inactivation. Although extracellular
Haihong Hu, Shaojun Zhou, Yi Peng, Yuru Liu, Zhiyuan Qin, Lushan Yu, Su Zeng   +6 more
doaj   +3 more sources

Neural Plasticity and Hearing‐Speech Development in Children with Auditory Brainstem Implants for Congenital Hearing Loss Due to Severe Inner Ear Malformation [PDF]

Advanced Science
Hearing and speech outcomes of pediatric patients with auditory brainstem implants (ABI) are variable, and the underlying developmental mechanism remains unexplored.
Yu Zhang, Yongchuan Chai, Yiwen Zhang, Huan Jia, Zhaoyan Wang, Zhihua Zhang, Zhili Wang, Jie Chen, Xue Wang, Yun Li, Ying Chen, Hao Wu   +11 more
doaj   +3 more sources

Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice [PDF]

eLife
mRNA vaccines emerged as a leading vaccine technology during the COVID-19 pandemic. However, their sustained protective efficacies were limited by relatively short-lived antibody responses and the emergence of SARS-CoV-2 variants, necessitating frequent ...
Chengcheng Fan, Alexander A Cohen, Kim-Marie A Dam, Annie V Rorick, Ange-Célia I Priso Fils, Zhi Yang, Priyanthi NP Gnanapragasam, Luisa N Segovia, Kathryn E Huey-Tubman, Woohyun J Moon, Paulo JC Lin, Pamela J Bjorkman, Magnus AG Hoffmann   +12 more
doaj   +2 more sources

Developing an eVLP mRNA vaccine for respiratory syncytial virus with enhanced pre-fusion targeting humoral responses [PDF]

Journal of Virology
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease (LRTD) in infants, the elderly, and immunocompromised individuals. In this study, we leveraged the innovative EABR (ESCRT- and ALIX-binding region) vaccine technology
Lei Sun, Mengting Huang, Simin Feng, Wei Zhang, Yun Quan, Ruyi Chen, Yupeng Yang, Haidong Xu, Wansheng Li, Qianyu Pan, Xinwen Chen, Danyang Zhang, Bin Yuan, Jincun Zhao, Zhongfang Wang, Jinzhong Lin, Wei Peng, Martin Ludlow, Qiong Zhang   +18 more
doaj   +2 more sources

Cochlear Implantation Following Neonatal Meningitis: A Rare Case Report [PDF]

Case Reports in Otolaryngology, Volume 2026, Issue 1, 2026.
Bacterial meningitis in neonates may lead to profound sensorineural hearing loss and rapid postinflammatory cochlear changes that complicate auditory rehabilitation. We present two infants with bilateral profound hearing loss following neonatal bacterial meningitis who underwent early bilateral cochlear implantation.
Dagmar Hošnová, Milan Urík, Jan Šíma, Vít Kruntorád, Anuja Salgaonkar   +4 more
wiley   +2 more sources

Improved mRNA-based RSV vaccine with PreF forming enveloped virus-like particles [PDF]

npj Vaccines
Respiratory syncytial virus (RSV) causes severe respiratory disease in infants and the elderly. However, natural infection fails to induce durable immune protection, and existing mRNA vaccines for older adults exhibit limited long-term efficacy.
Pengdi Chai, Yi Shi, Xiaoyan Li, Mengyao Yang, Xiafei Liu, Mei Liu, Junjie Yu, Xiaoxuan Yin, Dongwei Li, Ke Li, Xiangyu Kong, Qin Zhang, Hong Wang, Xiaoman Sun, Jinsong Li, Lili Li, Dandi Li, Lili Pang, Xuancheng Lu, Zhaojun Duan   +19 more
doaj   +2 more sources

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design [PDF]

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +2 more sources

The audiologic characteristics for children with cochlear nerve deficiency and the association with the outcome of cochlear implant surgery [PDF]

Annals of Medicine
Objective The objective of this study was to investigate the audiological characteristics of children with cochlear nerve deficiency (CND) and their correlation with cochlear implantation (CI) prognosis.Methods The records of 48 patients (24 with ...
Ruirui Guan, Wenyun Luo, Wan Zhao, Jingwu Sun, Jiaqiang Sun, Chunyan Li, Xiaotao Guo   +6 more
doaj   +2 more sources

Intraoperative Cochlear Nerve Monitoring in Cochlear Implantation after Vestibular Schwannoma Resection [PDF]

Audiology Research, 2023
Background: The use of a cochlear implant (CI) for hearing rehabilitation after vestibular schwannoma (VS) resection is widely spreading. The procedure is usually performed simultaneously to tumor resection with a translabyrinthine approach.
Valerio Maria Di Pasquale Fiasca, Giulia Tealdo   +1 more
doaj   +2 more sources

A Cochlear Implant Performance Prognostic Test Based on Electrical Field Interactions Evaluated by eABR (Electrical Auditory Brainstem Responses).

PLoS ONE, 2016
BackgroundCochlear implants (CIs) are neural prostheses that have been used routinely in the clinic over the past 25 years. They allow children who were born profoundly deaf, as well as adults affected by hearing loss for whom conventional hearing aids ...
Nicolas Guevara, Michel Hoen, Eric Truy, Stéphane Gallego   +3 more
doaj   +2 more sources