Results 171 to 180 of about 2,756,091 (350)

Intratympanic dexamethasone microcrystals/lidocaine‐loaded PLGA non‐spherical microparticles for local drug delivery to the inner ear

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Optimized lidocaine‐loaded PLGA non‐spherical particles (LPNMs) and dexamethasone microcrystals (DEX MCs) were prepared. They were then mixed in sodium hyaluronate solution to obtain a co‐delivery system, administrated in guinea pigs to evaluate the pharmacokinetics and biocompatibility of the system.
Dongcheng Wang   +7 more
wiley   +1 more source

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Deleting Col6a3 exon 3 by CRISPR in mice results in centralized nuclei consistent with a myopathy phenotype mimicking collagen VI‐associated human disease Abstract Background Most mutations in the COL6A3 gene lead to collagen VI‐related myopathies. This is due to a reduced expression or mislocalization of the COL6A3 protein.
Michel ElChoueiry   +12 more
wiley   +1 more source

DNA-based prediction of external ear morphology in the Chinese population: an exploratory study. [PDF]

open access: yesPeerJ
Wang X   +9 more
europepmc   +1 more source

Behavior Decoding Delineates Seizure Microfeatures and Associated Sudden Death Risks in Mouse Models of Epilepsy

open access: yesAnnals of Neurology, EarlyView.
Objective Behavior and motor manifestations are distinctive yet often overlooked features of epileptic seizures. Seizures can result in transient disruptions in motor control, often organized into specific behavioral sequences that can inform seizure types, onset zones, and outcomes.
Yuyan Shen   +8 more
wiley   +1 more source

Temporal Bone Carcinoma Masquerading as Complicated Chronic Otitis Media. [PDF]

open access: yesClin Case Rep
Shrestha SR   +4 more
europepmc   +1 more source

Cutting‐Edge Advancements in Physical Stimulation for Spiral Ganglion Neuron Protection and Regeneration

open access: yesAdvanced NanoBiomed Research, EarlyView.
Physical stimulation strategies have emerged as a therapeutic avenue for the regeneration of spiral ganglion neurons. This review explores diverse physical stimulation modalities—including topographical modulation, electrical stimulation, and photostimulation—each operating through distinct mechanisms to regulate SGN biological behavior. By elucidating
Yuhan Bai   +7 more
wiley   +1 more source

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