Results 51 to 60 of about 762,616 (316)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Hyperostotic tympanic bone spicules in domestic and wild animal species [PDF]
, 2016 Hyperostotic tympanic bone spicules (HTBS), or "mucoperiosteal exostoses" (ME, syn.) are small, globular (>= 1 mm in diameter), mostly stalked and drumstick-like, bony structures, which arise from the inner wall of the tympanic bulla and project into the
Blutke, A +5 more
core +2 more sources
Arthritis Care &Research, Accepted Article.Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla +13 more
wiley +1 more source
Brazilian Journal of Otorhinolaryngology, 2012 Os objetivos deste estudo foram descrever e analisar as medidas timpanométricas obtidas com sonda de 226 e 1000 Hz; verificar correlação da timpanometria com o resultado das emissões otoacústicas e otoscopia; descrever as alterações.
Luciana Macedo de Resende +4 more
doaj +1 more source
Acta Acustica, 2022 Wideband acoustic immitance (WAI) measurements provide an objective means to detect pathological middle ear conditions. However, for ears of young infants, it is still difficult to make clear statements about the middle ear status based on WAI ...
Sankowsky-Rothe Tobias +2 more
doaj +1 more source
Brazilian Journal of Otorhinolaryngology, 2007 Papillomas are benign, however locally invasive tumors normally originated in the larynx and nasosinusal tract. These tumors can be described from their specific histological and morphologic characteristics. Recurrence is common if excision is inadequately performed.
de Menezes Santos Torres, Sandro +3 more
openaire +2 more sources
Arthritis Care &Research, Accepted Article.Background Relapsing polychondritis (RP) is a rare disease defined by recurrent cartilaginous inflammation. Anti‐collagen II (anti‐Col2) antibodies have been proposed as a diagnostic biomarker for RP, but their performance characteristics are not well defined.
Karyssa Stonick +6 more
wiley +1 more source
Deformation of avian middle ear structures under static pressure loads, and potential regulation mechanisms [PDF]
, 2018 Static pressure changes can alter the configuration and mechanical behavior of the chain of ossicles, which may affect the acoustic transfer function. In mammals, the Eustachian tube plays an important role in restoring ambient middle ear pressure, hence
Aerts, Peter +3 more
core +2 more sources
Brazilian Journal of Otorhinolaryngology, 2012 Os lactentes devem ser submetidos à triagem auditiva ao nascimento e, para que os resultados sejam completos, é necessário avaliar as condições de orelha média.
Michele Vargas Garcia +3 more
doaj +1 more source