Results 121 to 130 of about 491,700 (340)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Chemical Cauterisation versus Fat Plug Myringoplasty for Closure of Small Central Tympanic Membrane Perforation: A Prospective Interventional Study

Journal of Clinical and Diagnostic Research
Introduction: Perforation of the tympanic membrane is a commonly encountered problem in otolaryngology and often leads to conductive hearing loss as well as recurrent middle ear infections.
Paresh Chavan, Aishwarya Biradar, Vinod V Shinde, Mayur H Ingale, Madhura Gandhi   +4 more
doaj   +1 more source

Cellular Differences in the Cochlea of CBA and B6 Mice May Underlie Their Difference in Susceptibility to Hearing Loss

Frontiers in Cellular Neuroscience, 2019
Hearing is an extremely delicate sense that is particularly vulnerable to insults from environment, including drugs and noise. Unsurprisingly, mice of different genetic backgrounds show different susceptibility to hearing loss.
Huihui Liu, Huihui Liu, Huihui Liu, Gen Li, Gen Li, Gen Li, Jiawen Lu, Jiawen Lu, Jiawen Lu, Yun-Ge Gao, Yun-Ge Gao, Yun-Ge Gao, Lei Song, Lei Song, Lei Song, Geng-Lin Li, Geng-Lin Li, Geng-Lin Li, Hao Wu, Hao Wu, Hao Wu   +20 more
doaj   +1 more source

Hospital Admission Profile Related to Inner Ear Diseases in England and Wales. [PDF]

Healthcare (Basel), 2023
Taybeh EO, Naser AY.
europepmc   +1 more source

The Treatment of Suppurative Inflammation of the Mastoid Process Associated with Disease of the Middle Ear [PDF]

, 1890
W. Arbuthnot Lane
openalex   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Towards the Clinical Application of Gene Therapy for Genetic Inner Ear Diseases. [PDF]

J Clin Med, 2023
Lahlou G, Calvet C, Giorgi M, Lecomte MJ, Safieddine S.   +4 more
europepmc   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Application of Nanomedicine in Inner Ear Diseases. [PDF]

Front Bioeng Biotechnol, 2021
Lin Q, Guo Q, Zhu M, Zhang J, Chen B, Wu T, Jiang W, Tang W.   +7 more
europepmc   +1 more source