Results 81 to 90 of about 204,571 (299)

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care [PDF]

, 2019
The specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules.
Wang, De Yun, Kari Nadeau, Akdis, Cezmi A, O’Hehir, Robyn E., Akdis, Cezmi A., O'Hehir, Robyn E, Fokkens, Wytske J., Nadeau, Kari, O’Mahony, Liam, De Yun Wang, Pfaar, Oliver, Luo Zhang, Torres, Maria J, Wytske J. Fokkens, Fokkens, Wytske J, Cezmi A. Akdis, Diamant, Zuzana, Zuzana Diamant, Liam O’Mahony, Traidl-Hoffmann, Claudia, Claudia Traidl‐Hoffmann, Robyn E. O’Hehir, Breiteneder, Heimo, Thomas Eiwegger, Oliver Pfaar, O'Mahony, Liam, Heimo Breiteneder, Maria J. Torres, Torres, Maria J., Zhang, Luo, Eiwegger, Thomas   +30 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Clinical Approach After Complicated Ear Mold Fitting: A Case Series of Six Patients and Evaluation of Literature

, 2019
Objectives: Insertion of mold material into the middle ear is a complication of molding procedure for ear impression. These cases are referred to an ENT specialist. There is no standardized approach to this problem.
van Spronsen, Erik, Waterval, J. rôme J., Holland, Carlijn T. Q., Ebbens, Fenna A., van den Boer, Cindy   +4 more
core   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Diseases of the ear, nose and throat [PDF]

, 2014
Diseases of the ear, nose and ...
Hashemi, Fariba
core  

Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education

Advanced Science, EarlyView.
We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua, Anira Escrichs, Yonatan Sanz Perl, Morten L. Kringelbach, Adele Diamond, Solange Denervaud, Gustavo Deco   +6 more
wiley   +1 more source

Achieving High‐Density and Stress‐Resilient Maize Breeding Via Germplasm Innovation

Advanced Science, EarlyView.
Global population growth and climate change have exacerbated the global food crisis. This perspective presents a conceptual framework focusing on enhancing population advantages. Several novel breeding objectives are proposed to improve density tolerance and stress resistance for yield improvement.
Xinlong Li, Yongqiang Chen, Dong Ding, Xuehai Zhang, Xuxiang Jia, Zhanhui Zhang, Yafei Wang, Weihua Li, Hui Zhang, Jihua Tang   +9 more
wiley   +1 more source

Co-occurrence of Otologic Disorders and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis [PDF]

Clinical and Experimental Otorhinolaryngology
Objectives. This systematic review was performed to investigate the co-occurrence of otologic disorders and benign paroxysmal positional vertigo (BPPV). Methods. Searches were conducted in PubMed and Web of Science.
Mustafa Karabulut, Sevgi Kutlu, Wolfgang Viechtbauer, Ali Melliti, Cem Meço, Alfarghal Mohamad, Osman Nuri Özgirgin, Anita Bhandari, Herman Kingma, Raymond van de Berg   +9 more
doaj   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

The advancements in understanding the pathogenesis of ear fullness

Journal of Otology
The sensation of ear fullness is a prevalent symptom encountered in clinical practice at ear clinics. It can manifest in various conditions, including external auditory canal diseases, middle ear diseases, inner ear diseases, as well as non-ear related ...
Shimin Zong, Wenting Yu, Xuan Yu, Ting Li, Wei Tang, Tianyi Liu, Hongjun Xiao   +6 more
doaj   +1 more source