Results 91 to 100 of about 54,647 (338)

Several cases of malignant neoplasms of the ear

open access: yesKazan medical journal, 1930
Meetings of medical societies. Society of Physicians at Kazan University.Rhino-laryngo-otiatric section.25th meeting 2 March 1929Several cases of malignant neoplasms of the ear observed in Kazan ARF clinics over 3 ...
openaire   +2 more sources

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

open access: yesAdvanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi   +10 more
wiley   +1 more source

Transplantable melanomas in hamsters and gerbils as models for human melanoma : sensitization in melanoma radiotherapy : from animal models to clinical trials [PDF]

open access: yes, 2018
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption
Andrzej Słominski   +11 more
core   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

open access: yesAdvanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan   +9 more
wiley   +1 more source

The evaluation of head and neck neoplasm in young and old adults

open access: yesSocial Determinants of Health, 2019
Background: Head and neck neoplasm (HNN) is one of the most common neoplasms in 6th and 7th of life. Its incidence rate is different in various human societies.
Mahbobeh Oroei   +4 more
doaj   +1 more source

An unusual unifocal presentation of Castleman’s disease in a young woman with a detailed description of sonographic findings to reduce diagnostic uncertainty: a case report [PDF]

open access: yes, 2013
Background: Castleman’s disease is a rare lymphoproliferative disorder. It typically presents as mediastinal masses and causes a wide range of clinical symptoms.
Maden, Zerrin, Wagner, Norbert
core   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

open access: yesAdvanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang   +12 more
wiley   +1 more source

Olfactory Neuroblastoma: Diagnostic Difficulty [PDF]

open access: yes, 2011
Olfactory neuroblastoma is an uncommon malignant tumor of sinonasal tract arising from the olfactory neuro epithelium. The olfactory neuroblastomas presenting with divergent histomorphologies like, epithelial appearance of cells, lacking a neuro ...
Biswas, Siddhartha   +3 more
core   +1 more source

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