Results 111 to 120 of about 10,275 (255)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2011 The earliness/tardiness (E/T) case of Hybrid Flow-shop Scheduling problem (HFSP) is an NP hard problem, which is difficult to deal with, however, the local assignment existing in the practical production increases the complexity of this problem.
Han ZH(韩忠华) +3 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Beam search algorithms for the early/tardy scheduling problem with release dates [PDF]
In this paper we consider the single machine earliness/tardiness scheduling problem with di?erent release dates and no unforced idle time. We present several heuristic algorithms based on the beam search technique. These algorithms include classical beam
Rui A. F. S. Alves, Jorge M. S. Valente
core
ISPEC Journal of Agricultural SciencesThis study aimed to investigate the effects of different planting and pruning systems on earliness, fruit quality, and some photosynthetic parameters in Mikado (apricot), Patagonia (nectarine), Papaz (plum), and Laurenne (almond) varieties grown in ...
Songül ÇÖMLEKÇİOĞLU +1 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 1999 Relationship between earliness and some morphological characteristics in watermelon were investigated. A total often genotypes belonging to very early, early, mid-early, late and very late fruiting groups were used in the experiment.
Abak K., Onsinejad R.
core +1 more source