Results 71 to 80 of about 35,427 (310)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Genesis and tectonic significance of Carboniferous volcanic rocks in Karamali area, northern Xinjiang

Youqi dizhi yu caishoulu
Volcanic rocks， such as andesite and tuff， are widely developed in the Carboniferous system in Karamali area， northern Xinjiang. The tectonic background of their formation is still controversial.
GAO Yongjin, CHEN Yi, SUN Xiangcan, WEN Lei, WANG Qianjun, BAI Zhongkai, TAN Zhilong, WANG Xinshui, XIN Yunlu, ZHANG Yuanyin, ZHU Depeng   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Sb ± Au mineralizing peak at 360 Ma in the Variscan belt

BSGF - Earth Sciences Bulletin, 2019
40Ar/39Ar absolute dating on tobelite (an ammonium-rich white mica) has been performed in order to provide geochronological constraints on the Sb ± Au mineralization and hydrothermalism at the Saint-Aubin-des-Châteaux base metal-Sb ± Au occurrence ...
Pochon Anthony, Branquet Yannick, Gloaguen Eric, Ruffet Gilles, Poujol Marc, Boulvais Philippe, Gumiaux Charles, Cagnard Florence, Baele Jean-Marc, Kéré Inoussa, Gapais Denis   +10 more
doaj   +1 more source

New basal Odonatoptera (Insecta) from the lower Carboniferous (Serpukhovian) of Argentina [PDF]

, 2016
Nuevos Odonatoptera basales del Serpukhoviano superior (325-324 Ma) son descriptos de la localidad Guandacol 1, Quebrada de las Libélulas, Formación Guandacol, provincia de La Rioja, centro oeste de la Argentina.
Gutierrez, Pedro Raul, Petrulevicius, Julian Fernando   +1 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A revision of tetrapod footprints from the late Carboniferous of the West Midlands, UK [PDF]

PeerJ, 2016
A series of sandstone slabs from Hamstead, Birmingham (West Midlands, UK), preserve an assemblage of tetrapod trackways and individual tracks from the Enville Member of the Salop Formation (late Carboniferous: late Moscovian–Kasimovian).
Luke E. Meade, Andrew S. Jones, Richard J. Butler   +2 more
doaj   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Complementary responses of stream fish and benthic macroinvertebrate assemblages to environmental drivers in a shale-gas development area

FACETS, 2020
Shale-gas production could impact freshwater quality through contamination of the physical and chemical habitat (e.g., fracturing fluids, untreated or treated effluent) or development-related impacts.
Jennifer Lento, Michelle A. Gray, Allison J. Ferguson, R. Allen Curry   +3 more
doaj   +1 more source

Nueva información palinológica sobre la Formación Poti (Viseano superior) en el arroyo Roncador, Cuenca Parnaíba, noreste de Brasil [PDF]

, 2014
Se presenta el resultado del análisis palinológico de seis muestras de superficie de la Formación Poti expuesta en el arroyo Roncador (Jerumenha, Piauí), noreste de Brasil.
Di Pasquo Lartigue, Maria, Iannuzzi, R.
core   +1 more source