Results 231 to 240 of about 9,208,125 (300)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Early Detection Methods for Autism Spectrum Disorder: From Clinical Screening to Multimodal AI. [PDF]

Diagnostics (Basel)
Luo W, Yin Z, Dai J.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Interventional Keratoconus Management: The Critical Imperative for Early Detection and Treatment. [PDF]

Clin Ophthalmol
Hatch KM, Donnenfeld E, Morgenstern AS, Ibach MJ.   +3 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Modeled Sojourn Time and Sensitivity for Detecting Preclinical Cancers Retrospectively by a Multicancer Early Detection Test. [PDF]

Cancer Epidemiol Biomarkers Prev
Dai JY, Luebeck EG, Hazelton WD, Clarke CA, Hubbell E, Patel AV.   +5 more
europepmc   +1 more source

The Malaysian Society of Gastroenterology and Hepatology Consensus Statements on Prevention and Early Detection of Hepatocellular Carcinoma in Malaysia. [PDF]

J Gastroenterol Hepatol
Lau SY, Kok VS, Tan SS, Adnan SD, Ng WL, Ang BH, Yaacob NY, Lee YY, Kaur S, Mohamed R, Wong PF, Lim LL, Letchumanan M, Vethakkan SR, Noor NM, Tan SF, Low TL, Kiew LB, Chan WK.   +18 more
europepmc   +1 more source

Metabolomics Reveals Potential Biomarkers for Early Detection of irAEs in ICI-Treated Patients. [PDF]

Drug Des Devel Ther
Fan W, Ma H, Zhang Y, Yin W, Qian C, Zang F, Zhang R, Lin B.   +7 more
europepmc   +1 more source