Results 161 to 170 of about 3,819,422 (303)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Restoring expression of tumour suppressor PTEN by engineered circular RNA‐enhanced Osimertinib sensitivity in non‐small cell lung cancer

Clinical and Translational Medicine
Haoran Li, Zheng Liu, Shaoyi Chen, Jingsheng Cai, Peiyu Wang, Kezhong Chen, Mantang Qiu   +6 more
doaj   +1 more source

Early Diagnosis of Degenerative Cervical Myelopathy: A Systematic Review of Current Evidence. [PDF]

Global Spine J
Russo F, Brigato P, Papalia GF, Fazzi N, Foglia P, Vadalà G, Papalia R, Denaro V.   +7 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

China National Guideline of Classification, Diagnosis and Treatment for Lung Nodules (2016 Version)

Chinese Journal of Lung Cancer, 2016
Qinghua ZHOU, Yaguang FAN, Ying WANG, Youlin QIAO, Guiqi WANG, Yunchao HUANG, Xingyun WANG, Ning WU, Guozhen ZHANG, Xiangpeng ZHENG, Hong BU   +10 more
doaj   +1 more source

Creative and Adaptive Solutions for Early Diagnosis of Sickle Cell Disease in Sub-Saharan Africa. [PDF]

Am J Hematol
Smart LR, Segbefia CI, Odame I.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Cell-free mitochondrial DNA and microRNA-137 for early diagnosis of preeclampsia. [PDF]

Front Cardiovasc Med
Marek-Iannucci S, Tigano M, Cardetti C, Sheu SS, Gamero Huaman M, Alvarez RJ, Rame E, Boelig RC, Rajapreyar IN.   +8 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Central Retinal Artery Occlusion: Early Diagnosis With Advanced Ultrasound Transorbital Doppler Imaging. [PDF]

Neurology
Merli N, Inchingolo V, Malferrari G, Pugliatti M, Paciaroni M.   +4 more
europepmc   +1 more source