Results 141 to 150 of about 1,564,555 (265)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Ten years of Descemet membrane endothelial keratoplasty: Identifying risk factors and early failure signs. [PDF]

Indian J Ophthalmol
Mechleb N, Rizk M, Debellemanière G, Gatinel D, Saad A.   +4 more
europepmc   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

[Analysis of risk factors for early failure of simple taper retentive implants]. [PDF]

Hua Xi Kou Qiang Yi Xue Za Zhi
Zhang X, Wan Z, Wei S, Yu F, Cao N, Cao L, Wu H, Guo S, Wei H.   +8 more
europepmc   +1 more source

Early failure of cement with loosening and dislocation of the femoral component in a unicompartmental knee replacement: a case report with microscopic assessment. [PDF]

Acta Biomed, 2022
Mancuso F, Di Benedetto P, Colombo E, Miani E, Fedrizzi L, Buttironi MM, Causero A.   +6 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Endovascular salvage of early failure of arteriovenous fistula by transradial arterial and retrograde venous fistuloplasty and stenting. [PDF]

J Vasc Surg Cases Innov Tech
Chong RC, Blah T, Katib N, Warburton T, Varcoe R, Thomas S.   +5 more
europepmc   +1 more source

Comment on: Factors affecting the early and mid-term success of needling for early failure of filtering bleb. [PDF]

Indian J Ophthalmol, 2021
Singla E, Ichhpujani P.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Risk of Bias When Using Early Failure Criteria in Randomized Clinical Trials With Stereoacuity Outcomes. [PDF]

Transl Vis Sci Technol
Panjwani M, Holmes JM.
europepmc   +1 more source