Results 91 to 100 of about 9,813 (265)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Summer paleohydrology during the Late Glacial and Early Holocene based on δ²H and δ¹⁸O from Bichlersee, Bavaria. [PDF]

Sci Rep, 2023
Prochnow M, Strobel P, Bliedtner M, Struck J, Bittner L, Szidat S, Salazar G, Schneider H, Acharya S, Zech M, Zech R.   +10 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Linked fire activity and climate whiplash in California during the early Holocene. [PDF]

Nat Commun, 2022
Homann J, Oster JL, de Wet CB, Breitenbach SFM, Hoffmann T.   +4 more
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

From everywhere all at once: Several colonization routes available to Svalbard in the early Holocene. [PDF]

Ecol Evol, 2023
Brožová V, Bolstad JS, Seregin AP, Eidesen PB.   +3 more
europepmc   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Continuous Centennial Late Glacial-Early Holocene (15-10 cal kyr BP) Palynological Record from the Iberian Pyrenees and Regional Comparisons. [PDF]

Plants (Basel), 2023
Rull V, Blasco A, Calero MÁ, Blaauw M, Vegas-Vilarrúbia T.   +4 more
europepmc   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Human remains from Arma di Nasino (Liguria) provide novel insights into the paleoecology of early Holocene foragers in northwestern Italy. [PDF]

Sci Rep, 2023
Sparacello VS, Goude G, Varalli A, Dori I, Gravel-Miguel C, Riel-Salvatore J, Palstra SWL, Moggi-Cecchi J, Negrino F, Starnini E.   +9 more
europepmc   +1 more source