Results 171 to 180 of about 1,850,573 (315)

Prediction Models for Early Identification of Overweight and Obese Children-A National Study. [PDF]

Nutrients
Sadaka IL, Grotto I, Sadaka Y, Eilenberg R, Peleg A, Greenberg D.   +5 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Establishment of multiple predictive models for early identification of the dengue cases in outpatient healthcare systems. [PDF]

Sci Rep
Xu Y, Guo C, Zhu Q, Zheng P, Yang Z, Zhang X, Zhong J, Zhou M, Zhou Z.   +8 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The NAVIGATE trial: early identification and management of mild acute hypoxemic failure, does timing matter outside ICUs? [PDF]

J Thorac Dis
Frat JP, Coudroy R, Thille AW.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Early Identification of Children at Risk for Long-Term Difficulties with Mathematics Learning and Innumeracy in Adolescence. [PDF]

J Pediatr Neuropsychol
Ferrer E, Geary DC, Shaywitz BA, Holahan JM, Shaywitz SE.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Early Hearing Detection and Intervention Program [PDF]

Data Source: 2020 CDC Early Hearing Detection and Intervention (EHDI) Hearing Screening & Follow-up Survey (HSFS)The CDC\u2019s National Center on Birth Defects and Developmental Disabilities promotes the health of babies, children, and adults, with a ...

core  

Early identification of neoadjuvant therapy non-response via multimodal immune-imaging biomarkers in breast cancer. [PDF]

Front Immunol
Zhou X, Huang X, Liu L, Cai X, Li H, Sun Z, Qiu Z, Zhong J, Yu T, Zeng Q.   +9 more
europepmc   +1 more source