Results 51 to 60 of about 1,850,573 (315)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Identification and expression of a murine cytomegalovirus early gene coding for an Fc receptor [PDF]

, 1994
Several herpesviruses, including cytomegalovirus, induce receptors for the Fc domain of murine immunoglobulin G (IgG) molecules. Viral genes coding for these receptors have been characterized only for alphaherpesviruses. In this report, we describe a new
Ulrich, Eggers, Maren, H. Koszinowski, Regine Thale, Karin Schneider, Thäle, Regine, Koszinowski, Ulrich H., Lucin, Pero, Schneider, Karin, Maren Eggers, Pero Lucin   +10 more
core  

Very Early Identification and Intervention for Infants at Risk of Neurodevelopmental Disorders: A Transdiagnostic Approach

, 2019
Neurodevelopmental disorders (NDDs) begin in the earliest months of life, but the clinical manifestations of many such disorders—including intellectual disability, autism spectrum disorder, attention‐deficit hyperactivity disorder, and fetal alcohol ...
Alvares, Gail, Jenny Downs, Leonard, Helen, Downs, Jenny, Helen Leonard, Amy Finlay‐Jones, Kandice Varcin, Bosco, Anthony, Anthony Bosco, Gail Alvares, Finlay‐Jones, Amy, Varcin, Kandice   +11 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Usefulness of Electronic Health Records From Preventive Youth Healthcare in the Recognition of Child Mental Health Problems

Frontiers in Public Health, 2021
Background and Objectives: Early identification of child mental health problems (MHPs) is important to provide adequate, timely treatment. Dutch preventive youth healthcare monitors all aspects of a child's healthy development. We explored the usefulness
Nynke R. Koning, Frederike L. Büchner, Anouk W. van den Berg, S. Y. Angelique Choi, Nathalie A. Leeuwenburgh, Irma J. M. Paijmans, D. J. Annemarie van Dijk-van Dijk, Mattijs E. Numans, Mathilde R. Crone   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Screen time characteristics and early-term parental concerns of children newly diagnosed with autism spectrum disorder (eng)

Klinik Psikiyatri Dergisi, 2020
INTRODUCTION[|]Aim of this study was to explore the screen characteristics of children who have been newly diagnosed with Autism Spectrum Disorder (ASD) and context of initial concerns of parents at the time of the first diagnosis.
Murat Eyüboğlu, Damla Eyüboğlu
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Clinical laboratory testing for smoking toxicity: implications for early identification of respiratory diseases

, 2016
Smoking toxicity has short and long term clinical effects and also leads to organ damage. However, clinical assessment in the context of early identification of smoke toxicity by evidence-base pathology is yet to be practiced. The present study was aimed
Bwititi, Phillip T., Nwose, Ezekiel U., Richards, Ross S.   +2 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source