Results 41 to 50 of about 895,320 (309)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

The cultures of the Early Iron Age in China as a part of the Scythian World

Материалы по археологии и истории античного и средневекового Причерноморья, 2021
Based on archaeological and written sources, the authors characterizes the two ethno cultural regions of the 9th — 3rd centuries BCE that developed in the east of the Scythian world — in Xinjiang and North China.
Shulga, P.I. , Shulga, D.P.
doaj   +1 more source

Early cow's milk introduction is associated with failed personal-social milestones after 1 year of age [PDF]

, 2014
Both the American Academy of Pediatrics (AAP) and the Institute of Medicine (IOM) recommend delaying the introduction of cow's milk until after 1 year of age due to its low absorbable iron content.
Bennett, William E., Carroll, Aaron E., Downs, Stephen M., Hendrix, Kristin S., Thompson-Fleming, Rachel T.   +4 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Raman Investigations to Identify Corallium rubrum in Iron Age Jewelry and Ornaments [PDF]

, 2016
International audienceDuring the Central European Iron Age, more specifically between 600 and 100 BC, red precious corals (Corallium rubrum) became very popular in many regions, often associated with the so-called (early) Celts.
Bellot-Gurlet, Ludovic, Fürst, Sebastian, Gianni, Liliana, Müller, Katharina, Pare, Christopher F.E., Paris, Céline, Reiche, Ina   +6 more
core   +5 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Archaeometallurgical Explorations of Bloomery Iron Smelting at Mutoti 2, an Early Iron Age Site in Venda, Northern South Africa

Metals, 2023
When established, bloomery iron smelting profoundly transformed farming communities that settled in Africa south of the Sahara. Sustained research in the Lowveld region of northern South Africa identified multifarious evidence of metal working dating to ...
Eric N. Mathoho, Robert T. Nyamushosho, Shadreck Chirikure   +2 more
doaj   +1 more source

Living on the lake in the Iron Age: new results from aerial photographs, geophysical survey and dendrochronology on sites of Biskupin type [PDF]

, 2013
© 2010 Antiquity PublicationsThe article publishes new photographs and geophysical survey plans of a series of sites of the Early Iron Age in Poland, and provides new dating evidence from dendrochronology.
Harding, Anthony, Rączkowski, Włodzimierz   +1 more
core