Risk factors for anorexia nervosa: A population‐based investigation of sex differences in polygenic risk and early life exposures [PDF]
, 2023 Hannah Chatwin +9 more
openalex +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Early Triassic conodonts from the Liangshan area, Hanzhong, Shaanxi, South China [PDF]
Journal of MicropalaeontologyThe Liangshan area in Hanzhong city, Shaanxi Province, China, is in the northwestern part of the Yangtze Platform. Strata across the Permian–Triassic boundary (PTB) are continuous, well developed, and fossiliferous, providing an ideal place for ...
Y. Zhao +7 more
doaj +1 more source
Early life adversity and health‐risk behaviors: proposed psychological and neural mechanisms
Annals of the New York Academy of Sciences, 2018 Early life adversity (ELA) is associated with poorer health in adulthood, an association explained, at least in part, by increased engagement in health‐risk behaviors (HRBs).
Korrina A. Duffy +2 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Exogenous determinants of early-life conditions, and mortality later in life [PDF]
We analyze causal effects of conditions early in life on the individual mortality rate later in life. Conditions early in life are captured by transitory features of the macro environment around birth, notably the state of the business cycle around birth,
Gabriele Doblhammer-Reiter +2 more
core
A large-scale population study of early life factors influencing left-handedness
Scientific Reports, 2018 Hand preference is a conspicuous variation in human behaviour, with a worldwide proportion of around 90% of people preferring to use the right hand for many tasks, and 10% the left hand.
Carolien G. F. de Kovel +2 more
semanticscholar +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Diversity of Human Milk Oligosaccharides and Effects on Early Life Immune Development
Frontiers in Pediatrics, 2018 One of the well-known features of human milk, is the capacity to protect against the risk and impact of neonatal infections, as well as to influence the onset of allergic and metabolic disease manifestations.
Veronica Ayechu-Muruzabal +6 more
semanticscholar +1 more source
Early aspects: aspect-oriented requirements engineering and architecture design [PDF]
, 2004 This paper reports on the third Early Aspects: Aspect-Oriented Requirements Engineering and Architecture Design Workshop, which has been held in Lancaster, UK, on March 21, 2004.
Araújo, João +3 more
core +4 more sources