Results 131 to 140 of about 19,801,094 (386)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Impact of Early and Recent Life Stress on Trajectories of Inflammatory Biomarkers in a Diverse Sample of Adolescents [PDF]

, 2023
Marin Kautz, Brae Anne McArthur, Daniel P. Moriarity, Lauren M. Ellman, Joshua Klugman, Christopher L. Coe, Lyn Y. Abramson, Lauren B. Alloy   +7 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Autism spectrum disorder common variants associated with regional lobe volume variations at birth: cross-sectional study in 273 European term neonates in developing human connectome project

Translational Psychiatry
Increasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population.
Hai Le, Daphna Fenchel, Konstantina Dimitrakopoulou, Hamel Patel, Charles Curtis, Lucilio Cordero-Grande, A. David Edwards, Joseph Hajnal, Jacques-Donald Tournier, Maria Deprez, Harriet Cullen   +10 more
doaj   +1 more source

Anamorphic development and extended parental care in a 520 million-year-old stem-group euarthropod from China

BMC Evolutionary Biology, 2018
Background Extended parental care is a complex reproductive strategy in which progenitors actively look after their offspring up to – or beyond – the first juvenile stage in order to maximize their fitness.
Dongjing Fu, Javier Ortega-Hernández, Allison C Daley, Xingliang Zhang, Degan Shu   +4 more
doaj   +1 more source

Testing the effect of early‐life reproductive effort on age‐related decline in a wild insect [PDF]

, 2018
Rolando Rodríguez‐Muñoz, Jelle J. Boonekamp, Xing P. Liu, Ian Skicko, David N. Fisher, Paul Hopwood, Tom Tregenza   +6 more
openalex   +1 more source

Infants Receiving Very Early Antiretroviral Therapy Have High CD4 Counts in the First Year of Life [PDF]

, 2022
Bryan S Nelson, Camlin Tierney, Deborah Persaud, Jennifer Jao, Mark F. Cotton, Yvonne J. Bryson, Anne Coletti, Theodore Ruel, Stephen A. Spector, Christina Reding, Kira Bacon, Diane Costello, Charlotte Perlowski, Maria Letícia Santos Cruz, Josphat Kosgei, Sai Majji, Dwight E. Yin, Patrick Jean‐Philippe, Ellen G. Chadwick   +18 more
openalex   +1 more source

Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

Nature Communications, 2017
There is increasing concern about potential long-term effects of antibiotics on children’s health. Epidemiological studies have revealed that early-life antibiotic exposure can increase the risk of developing immune and metabolic diseases, and rodent ...

semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Nutritional regulation of fetal growth and implications for productive life in ruminants

Animal, 2010
The maternal nutritional and metabolic environment is critical in determining not only the reproductive success but also the long-term health and viability of the offspring.
M.E. Symonds, S.P. Sebert, H. Budge
doaj   +1 more source