Results 131 to 140 of about 20,037,007 (385)
Early-life adversity and cortisol response to social stress: a meta-analysis
Translational Psychiatry, 2017 Early-life adversity has been associated with a life-long increased risk for psychopathology and chronic health problems. These long-term negative effects have been explained through stress sensitization, which may involve dysregulation of the ...
I. Bunea +2 more
semanticscholar +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Early Triassic conodonts from the Liangshan area, Hanzhong, Shaanxi, South China [PDF]
Journal of MicropalaeontologyThe Liangshan area in Hanzhong city, Shaanxi Province, China, is in the northwestern part of the Yangtze Platform. Strata across the Permian–Triassic boundary (PTB) are continuous, well developed, and fossiliferous, providing an ideal place for ...
Y. Zhao +7 more
doaj +1 more source
From early life to senescence: individual heterogeneity in a long‐lived seabird [PDF]
, 2017 Rémi Fay +3 more
openalex +1 more source
Metabolic programming in early life in humans
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019 An association of low birth weight with an increased risk of adult cardiovascular disease and diabetes led to the developmental origins of health and disease (DOHaD) hypothesis, which proposes that undernutrition during early development permanently ...
C. Fall, K. Kumaran
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Translational PsychiatryIncreasing lines of evidence suggest cerebral overgrowth in autism spectrum disorder (ASD) children in early life, but few studies have examined the effect of ASD common genetic variants on brain volumes in a general paediatric population.
Hai Le +10 more
doaj +1 more source