Results 151 to 160 of about 19,801,094 (386)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Altered structural brain development has been identified in fetuses with congenital heart disease (CHD), suggesting that the neurodevelopmental impairment observed later in life might originate in utero. There are many interacting factors that
Siân Wilson, Daniel Cromb, Alexandra F. Bonthrone, Alena Uus, Anthony Price, Alexia Egloff, Milou P. M. Van Poppel, Johannes K. Steinweg, Kuberan Pushparajah, John Simpson, David F. A. Lloyd, Reza Razavi, Jonathan O'Muircheartaigh, A. David Edwards, Joseph V. Hajnal, Mary Rutherford, Serena J. Counsell   +16 more
doaj   +1 more source

Gender Differences in Competition Emerge Early in Life [PDF]

We study gender differences in the willingness to compete in a large-scale experiment with 1,035 children and teenagers, aged three to eighteen years. Using an easy math task for children older than eight years and a running task for the younger ones we ...
Rützler, Daniela, Sutter, Matthias
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Reactive Melt Flow in the Continental Arc Root: Insights for the Transition From Gabbronorite to Garnet Granulite in the Central Qilian Belt, NE Tibet

Geochemistry, Geophysics, Geosystems
Understanding reactive melt flow is crucial for advancing our knowledge of crustal differentiation; however, the mechanisms governing melt migration remain debated, particularly in deep magmatic arc environments.
Xiao‐Kui Sun, Chao Wang, Nathan R. Daczko, Xiao‐Ying Liao, Ji‐Heng Zhang, Wen‐Qiang Yang, Liang Liu   +6 more
doaj   +1 more source

Identifying Early-Life Behavior to Predict Mothering Ability in Swine Utilizing NUtrack System [PDF]

, 2023
Savannah Millburn, Ty B Schmidt, G. A. Rohrer, Benny E Mote   +3 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Millennial-scale surface hydrological variability in the tropical eastern Indian Ocean linked to Northern Hemisphere high latitudes

Frontiers in Marine Science
Surface hydrology in the tropical eastern Indian Ocean significantly impacts low-latitude climate processes including the Indonesian-Australian Monsoon and the Indian Ocean Dipole.
Rui Cui, Peng Zhang, Jian Xu, Ann Holbourn, Wolfgang Kuhnt   +4 more
doaj   +1 more source

The association between early life mental health and alcohol use behaviours in adulthood: A systematic review

, 2020
Ke Ning, Dawid Gondek, Praveetha Patalay, George B. Ploubidis   +3 more
openalex   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source