Results 151 to 160 of about 20,037,007 (385)

Simple model for the Darwinian transition in early evolution

, 2015
It has been hypothesized that in the era just before the last universal common ancestor emerged, life on earth was fundamentally collective. Ancient life forms shared their genetic material freely through massive horizontal gene transfer (HGT).
Arnoldt, Hinrich, Strogatz, Steven H., Timme, Marc   +2 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Early life encounters [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Reactive Melt Flow in the Continental Arc Root: Insights for the Transition From Gabbronorite to Garnet Granulite in the Central Qilian Belt, NE Tibet

Geochemistry, Geophysics, Geosystems
Understanding reactive melt flow is crucial for advancing our knowledge of crustal differentiation; however, the mechanisms governing melt migration remain debated, particularly in deep magmatic arc environments.
Xiao‐Kui Sun, Chao Wang, Nathan R. Daczko, Xiao‐Ying Liao, Ji‐Heng Zhang, Wen‐Qiang Yang, Liang Liu   +6 more
doaj   +1 more source

Structural Covariance Networks in the Fetal Brain Reveal Altered Neurodevelopment for Specific Subtypes of Congenital Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Altered structural brain development has been identified in fetuses with congenital heart disease (CHD), suggesting that the neurodevelopmental impairment observed later in life might originate in utero. There are many interacting factors that
Siân Wilson, Daniel Cromb, Alexandra F. Bonthrone, Alena Uus, Anthony Price, Alexia Egloff, Milou P. M. Van Poppel, Johannes K. Steinweg, Kuberan Pushparajah, John Simpson, David F. A. Lloyd, Reza Razavi, Jonathan O'Muircheartaigh, A. David Edwards, Joseph V. Hajnal, Mary Rutherford, Serena J. Counsell   +16 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Late gestation MRI to assess maternal pelvimetry, fetal biometry and placental oxygenation: a retrospective pilot study

BMC Pregnancy and Childbirth
Background The role of MRI pelvimetry and fetal size estimation in predicting mode of birth and risk of operative birth have been studied. However, there are no complete MRI studies that assess the maternal pelvis, fetal dimensions, and the placenta in a
Shireen Jaufuraully, Alena Uus, Jana Hutter, Simi Bansal, Bassel H. AL Wattar, Lisa Story, Dimitrios Siassakos, Anna L. David, Mary Rutherford   +8 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Millennial-scale surface hydrological variability in the tropical eastern Indian Ocean linked to Northern Hemisphere high latitudes

Frontiers in Marine Science
Surface hydrology in the tropical eastern Indian Ocean significantly impacts low-latitude climate processes including the Indonesian-Australian Monsoon and the Indian Ocean Dipole.
Rui Cui, Peng Zhang, Jian Xu, Ann Holbourn, Wolfgang Kuhnt   +4 more
doaj   +1 more source