Results 211 to 220 of about 20,037,007 (385)

The age separating early deaths from late deaths [PDF]

There is a unique threshold age separating early deaths from late deaths such that averting an early death decreases life disparity, but averting a late death increases inequality in lifespans.life disparity ...
James W. Vaupel, Zhen Zhang
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Early-Life Sodium Exposure Unmasks Susceptibility to Stroke in Hyperlipidemic, Hypertensive Heterozygous Tg25 Rats Transgenic for Human Cholesteryl Ester Transfer Protein

, 2009
Julius L. Decano, Jason Viereck, Ann C. McKee, James A. Hamilton, Nelson Ruiz‐Opazo, Victoria L. M. Herrera   +5 more
openalex   +1 more source

Pathophysiological trajectories and biological consequences of early life trauma [PDF]

, 2017
Agorastos Agorastos
openalex   +1 more source

Author response for "Associations between Body Mass Index Trajectories in the first two years of life and Allergic Rhinitis, Eczema and Food Allergy outcomes up to early adulthood"

, 2022
Chia‐Lun Chang, Gulshan Bano Ali, Caroline Lodge, Michael J. Abramson, Bircan Erbas, Mimi L.K. Tang, Cecilie Svanes, Dinh Bui, Shyamali C. Dharmage, Adrian J. Lowe   +9 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Coenzyme-protein interactions since early life. [PDF]

Elife
Sanchez Rocha AC, Makarov M, Pravda L, Novotný M, Hlouchová K.   +4 more
europepmc   +1 more source

Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs

, 2014
Michelle Herring, L. F. Putney, Judith A. St. George, Mark Avdalovic, Edward S. Schelegle, Lisa A. Miller, Dallas M. Hyde   +6 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Early Life Injury Alters Spinal Astrocyte Development. [PDF]

J Neurosci
Yoo JJ, Serafin EK, Kofron JM, Baccei ML.   +3 more
europepmc   +1 more source