Results 241 to 250 of about 20,037,007 (385)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Taxane-Induced Peripheral Neuropathy among Early-Stage Breast Cancer Survivors : Prevalence, Risk Factors, Quality of Life and Genetic Prediction Models

K. Engvall
openalex   +2 more sources

The Role of early-life psychological factors in the development of chronic disease: a longitudinal analysis applied to the onset of cancer, diabetes, and asthma in mid-life. [PDF]

, 2010
Reuben Ogollah
openalex  

Early-life gut mycobiome core species modulate metabolic health in mice [PDF]

Mackenzie W. Gutierrez, Erik van Tilburg Bernardes, Enbo Ren, Kristen Kalbfleisch, M. Day, Ewandson Luiz Lameu, Thaís Glatthardt, Emily M. Mercer, Sunita Sharma, Hong Zhang, Ali Al-Azawy, Faye Chleilat, Simon A. Hirota, Raylene A. Reimer, Marie‐Claire Arrieta   +14 more
openalex   +1 more source

Early-life inflammation, immune response and ageing [PDF]

, 2017
Imroze Khan, Deepa Agashe, Jens Rolff
openalex   +1 more source

Correlation of Great Chinese Famine Exposure During Early Life to Prevalence of Kidney Stone in Adulthood

, 2023
Yu-qin Yan, Yuqing Huang, Yingqing Feng
openalex   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

How Early-Life Programming During Embryogenesis Imprints Cellular Memory. [PDF]

Int J Mol Sci
Alfian NF, Uechi K, Morishita Y, Sato K, Yui M, Jharna JF, Bari MW, Ishiyama S, Mochizuki K, Kishigami S.   +9 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Early-Life Events and the Prevalence of Gut-Brain Interaction Disorders in Children. [PDF]

Children (Basel)
Chanpong A, Ponjorn N, Tassanakijpanich N, Koosakulchai V, Rachatawiriyakul P, Kittivisuit S, Khantee P, Laoprasopwattana K.   +7 more
europepmc   +1 more source