Results 241 to 250 of about 19,801,094 (386)

Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: a cross-species translational study

Minae Niwa, Sedona Lockhart, Daniel J. Wood, Kun Yang, José Fernando de Oliveira, Kyohei Kin, Adeel Ahmed, Gary S. Wand, Shin‐ichi Kano, Jennifer L. Payne, Akira Sawa   +10 more
openalex   +2 more sources

Early-life exposure to EDCs: role in childhood obesity and neurodevelopment

Nature Reviews Endocrinology, 2017
J. Braun
semanticscholar   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Only connect. The links between early and later life [PDF]

, 2007
Waddell, Margot
core  

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Interaction of early life stress and NAD + /SIRT1 pathway genetic risk promotes depression. [PDF]

Transl Psychiatry
Torok D, Krause S, Gecse K, Gal Z, Eszlari N, Csikos M, Bagdy G, Gonda X, Juhasz G, Petschner P.   +9 more
europepmc   +1 more source

Early Life Risk Factors That Contribute to Irritable Bowel Syndrome in Adults: A Systematic Review

, 2020
Denesh K. Chitkara, Miranda A.L. van Tilburg, Nannette Blois-Martin, William E. Whitehead   +3 more
openalex   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Influence of early life adversity and breed on aggression and fear in dogs. [PDF]

Sci Rep
Espinosa J, Zapata I, Alvarez CE, Serpell JA, Kukekova AV, Hecht EE.   +5 more
europepmc   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source