Results 251 to 260 of about 20,037,007 (385)

Prenatal and Early Life Fructose, Fructose-Containing Beverages, and Midchildhood Asthma

, 2017
Lakiea S. Wright, Sheryl L. Rifas‐Shiman, Emily Oken, Augusto A. Litonjua, Diane R. Gold   +4 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The Ontogenetic Development of Rapid Eye Movement Sleep in Early Life and Its Regulatory Mechanisms. [PDF]

Int J Dev Neurosci
Zhang XJ, Gao XH, Wang AH, Wang CQ, Liu J, Hu YL, Duan BW, Huang HY, Gao JX.   +8 more
europepmc   +1 more source

Only connect. The links between early and later life [PDF]

, 2007
Waddell, Margot
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Early-life factors contributing to type 1 diabetes

Diabetologia, 2019
M. Craig, K. W. Kim, Sonia R Isaacs, M. Penno, Emma E. Hamilton-Williams, J. Couper, W. Rawlinson   +6 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

In utero and early life exposures to smoking are associated with systemic autoimmune rheumatic diseases. [PDF]

Semin Arthritis Rheum
Ohnishi T, Zhao M, Shi M, Volochayev R, Jackson SH, Jansen A, Bayat N, Farhadi PN, Sarkar K, Flegel WA, Parks CG, Weinberg CR, Miller FW, Schiffenbauer A, Rider LG.   +14 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The effects of shocks in early life mortality on later life expectancy and mortality compression: A cohort analysis

, 2010
Mikko Myrskyl xe
openalex   +1 more source