This study optimizes a two‐step induction system to generate PGCLCs from chicken ESCs. The induced cells express germline markers and migrate to gonads in ovo, offering a novel approach for avian genetic resource conservation. Primordial germ cells (PGCs) are the progenitor cells of sperm and eggs.
Zeyu Li +10 more
wiley +1 more source
Early life grandmother caregiving trajectories and child development: a longitudinal study. [PDF]
Chung EO +6 more
europepmc +1 more source
Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life [PDF]
Katherine E. Prater +8 more
openalex +1 more source
Early-life factors contributing to type 1 diabetes
M. Craig +6 more
semanticscholar +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
The impact of early life stress on patient-reported outcomes in multiple sclerosis. [PDF]
Goldman M +4 more
europepmc +1 more source
Early‐life gut microbiome and egg allergy
Mina Fazlollahi +10 more
semanticscholar +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Early Life Exposure to the Great Chinese Famine and Cardiometabolic Outcomes.
Cao A +6 more
europepmc +1 more source
Special Issue: Diet and Lifestyle Factors Associated with Allergic Diseases in Early Life. [PDF]
Frei R.
europepmc +1 more source

