Results 311 to 320 of about 19,801,094 (386)

Long-term fitness effects of the early-life environment in a wild bird population. [PDF]

Behav Ecol
Sun Y, Burke TA, Dugdale HL, Schroeder J.   +3 more
europepmc   +1 more source

Early Life Exposure to Manure-Fertilized Soil Shapes the Gut Antibiotic Resistome

Zhiqiang Zhai, Likun Yang, Lizhong Zhu, Fang‐Jie Zhao, Wan‐Ying Xie, Peng Wang   +5 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Sex-Specific Associations of Early Life Exposure to the Pesticide Mixture with Cardiometabolic Outcomes in CHAMACOS Young Adults. [PDF]

Environ Sci Technol
Hu CY, Mora AM, Gunier RB, Rauch S, Kogut K, Gregory JK, Erkin-Cakmak A, Eskenazi B, Rosa MJ.   +8 more
europepmc   +1 more source

Early-life residential greenness and sleep disturbances in preschoolers across 551 cities of China

Yang Shen, Yan Zhao, Xia Meng, Kexin Yu, Gareth J. Williams, Wenchong Du, Jing Cai, Haidong Kan, Jing Hua   +8 more
openalex   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance. [PDF]

Immun Ageing
Buckley DJ, Zahedi S, Velusamy P, Sharma S, Sabnani M, Flores LC, Tandukar G, Ikeno Y, Fadel PJ, Lesniewski LA, Trott DW.   +10 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Early-Life Heat Stress Impairs Cognition and Alters Its Covariation With Behaviour in Zebrafish. [PDF]

Ecol Evol
Gatto E, Conti F, Bertolucci C, Lucon-Xiccato T.   +3 more
europepmc   +1 more source