Results 81 to 90 of about 460 (181)

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

The Effectiveness of schema therapy in reduction of Early maladaptive schemas on PTSD Veterans Men

Armaghane Danesh Bimonthly Journal, 2014
Background & aim: Despite the wide variety methods of psychological therapies for the treatment of post-traumatic stress disorder, still a significant number of patients do not respond to treatment or show a low relatively improvement.
SA Moosaviassl, Z Moosavi Sadat
doaj  

Speciation with gene flow

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long, Xu Zhang, Yue Yu, Gregory L. Owens, Diana J. Rennison, Clarisse Palma‐Silva, Daniel Ortiz‐Barrientos, Loren H. Rieseberg   +7 more
wiley   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

Modeling the structural relationship between early maternal maladaptive schemas and children\'s temperamental problems: The mediating role of child adjustment

Preventive Care in Nursing and Midwifery Journal, 2019
Background: The characteristics of maternal schemas play an important role in children’s psychological health. Identifying the mechanism of the relationship between maternal schema and temperament problems can be the focus of therapeutic interventions ...
Mohammad Kazem Salamat, Masoud Hejazi, Siros Izadpanah, Zekrollah Morovati   +3 more
doaj  

Gender Differences in Maladaptive Cognitive Schema in Orphans in Dakahlia, Egypt

The Scientific World Journal, 2013
The objective of this study was to assess the gender differences of maladaptive cognitive schema among orphans in Dakahlia governorate orphanages. A cross-sectional comparative study included 152 orphan boys and 48 orphan girls in all orphanages homes ...
Abdel-Hady El-Gilany, Mona A. El-Bilsha, Azza Ibrahim   +2 more
doaj   +1 more source

Effects of Live and Heat‐Treated Bifidobacterium longum CECT 7347 in Adults With Allergic Rhinitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial

Allergy, EarlyView.
This randomized, double‐blind, placebo‐controlled trial evaluated the effects of live probiotic and HT postbiotic B. longum CECT 7347 in adults with moderate–severe allergic rhinitis. Postbiotic supplementation for 8 weeks significantly reduced CSMS and dSS, exceeding the established CSMS MCID with a 33% greater improvement, when compared to placebo ...
Ana Cardoso, Malwina Naghibi, Eric Climent, Andrea Rodenes‐Gavidia, Araceli Lamelas, Laura Llobregat, Juan Martínez‐Blanch, Daniel Friedman, Vineetha Vijayakumar, Richard Day   +9 more
wiley   +1 more source

Early Maladaptive Schemas And Immigration: A Case Study

Yaşam Becerileri Psikoloji Dergisi, 2017
Savaş ve göç  yaşayan toplumlardaki bireyler travmatikyaşantılarını yaşamları boyunca taşımaktadırlar. Bireyler dünya ile ilgilialgılarını ve yaşantılarını belirli kalıplar içerisinde sınıflandırırlar. Busınıflandırma, yaşam deneyimleri ile elde edilen bilgilerdir.
openaire   +2 more sources

Do schema modes predict outcome of cognitive behavioural therapy in patients with obsessive–compulsive disorder and anxiety disorders?

British Journal of Clinical Psychology, EarlyView.
Abstract Objectives Cognitive behavioural therapy (CBT) is the psychological treatment of choice for patients with obsessive–compulsive disorder (OCD) or an anxiety disorder. However, a substantial group (30–40%) does not profit sufficiently. Predictors of outcome inform us about how to adapt interventions for this group.
Manon Peeters, Boris van Passel, Nancy Peeters, Julie Krans   +3 more
wiley   +1 more source