Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
QTL Mapping and Candidate Gene Analysis for Cotton Fiber Quality and Early Maturity Using F<sub>2</sub> and F<sub>3</sub> Generations. [PDF]
Jia X +6 more
europepmc +1 more source
Natural variation in a CENTRORADIALIS homolog contributed to cluster fruiting and early maturity in cotton. [PDF]
Liu D +15 more
europepmc +1 more source
Valuation of American Continuous-Installment Options [PDF]
In an American continuous-installment option the premium, instead of being paid up-front, is paid at a certain rate per unit time. At any time at or before maturity date, the holder has the right to terminate payments and either exercise the option or ...
Ilir Roko, Pierangelo Ciurlia
core
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
early maturity 7 promotes early flowering by controlling the light input into the circadian clock in barley. [PDF]
Helmsorig G +6 more
europepmc +1 more source
Editor's Spotlight/Take 5-Early Maturity as the New Normal: A Century-long Study of Bone Age. [PDF]
Leopold SS.
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
‘Isabella’: A New Early Maturity Pigeonpea
Diego M. Viteri +1 more
doaj +1 more source
Early maturity, shortened stature, and hardship: Can life-history trade-offs indicate social stratification and income inequality in the United States? [PDF]
Rivara AC, Madrigal L.
europepmc +1 more source

