Results 51 to 60 of about 4,821,814 (284)

Symptoms of Early Onset of Menopause in Women, A Cross-Sectional Study in District Shaheed Benazirabad [PDF]

Liaquat National Journal of Primary Care
Background: Early menopause is a significant public health concern as the reproductive health of women gets affected and predisposed to early risk, psychological, sexual, and other disorders, poor bone health, and chronic diseases.
Imran Mirbahar, Hanna Khair Tunio, Renuka Lohana, Nisha Kumari, Komal Jhamandas, Kanchan, Devyani Tehlwani   +6 more
doaj   +1 more source

Effects of Smoking on Menopausal Age: Results From the Korea National Health and Nutrition Examination Survey, 2007 to 2012 [PDF]

Journal of Preventive Medicine and Public Health, 2015
Objectives: Decreased fertility and impaired health owing to early menopause are significant health issues. Smoking is a modifiable health-related behavior that influences menopausal age.
Hee Jung Yang, Pae Sun Suh, Soo Jeong Kim, Soon Young Lee   +3 more
doaj   +1 more source

Understanding weight gain at menopause

, 2012
Objective: The aim of this review was to summarize the literature regarding the impact of the menopause transition on body weight and body composition.
Castelo-Branco, C., NAPPI, ROSSELLA, Shah, D., Davis, S.R., Lumsden M. A., Nappi, R.E., Villaseca, P., Lumsden, M.A., D. Villaseca, Lumsden, M. A., Davis, S. R., Castelo Branco, C., as the Writing Group of the International Menopause Society for World Menopause Day 2012, Chedraui, P., Nappi, R. E., Shah, P.   +16 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Menopause and the workplace

, 2019
Menopause is the stage in a woman’s life where she stops menstruating for good. On average, women reach menopause at 51; and perimenopause, the stage where they experience menopausal symptoms including hot flushes, anxiety and difficulties with ...
Brewis, Joanna
core   +5 more sources

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

The relation between variation in size of the primordial follicle pool and age at natural menopause [PDF]

, 2015
Context: Tumors producing insulin-like growth factor 2 (IGF-2oma) are a major cause of spontaneous hypoglycemia. The treatment mainstay is surgical resection.
van der Schouw, Yvonne, Nelson, S. M., Peeters, P. H M, Faddy, M.J., Peeters, P.H.M., Nelson, S.M., Peeters, Petra, Broer, S.L., Broer, S. L., van der Schouw, Y.T., Faddy, M J, Nelson, S M, Kelsey, T.W., Kelsey, Tom, Depmann, Martine, Depmann, M, Depmann, M., Faddy, M. J., Van Der Schouw, Y. T., Broekmans, F.J.M., Broekmans, Frank, Broekmans, F J M, van der Schoew, Y T, Broekmans, F. J M, Kelsey, T. W., Broer, Simone, Nelson, Scott, Peeters, P H M, Faddy, Malcolm, Broer, S L   +29 more
core   +2 more sources

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Early Menopause in Type 2 Diabetes – A Study from a South Indian Tertiary Care Centre [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Menopause marks the end of ovarian function and it is called ‘early’ or ‘premature’ if it occurs before 45 years. Very little is known about the menopause transition in Diabetic women.
T.V.D. Sasi Sekhar, Soumya Medarametla, Arifa Rahman, Satya Sahi Adapa   +3 more
doaj   +1 more source